In the Bering Sea, summer dimethylsulfide (DMS) and dimethylsulfoniopropionate (DMSPd and DMSPp) exhibited substantial spatial and interannual variations during 2012–2016, encompassing both cold (2012) and warm (2014 and 2016) temperature regimes. Summer average chlorophyll a, DMS, and DMSPd concentrations in the upper water increased significantly, paralleling a 1.6 °C increase in seawater temperature. High DMS/DMSPp regions in the upper 50 m at 177°E–175°W extended both north‐eastward and south‐westward, which were associated with elevated phytoplankton biomass and concurrent proportion of dinoflagellates in phytoplankton community in warm years. Simultaneously, these patches spread vertically throughout the upper 200 m in warm years, which corresponded with rapid bacteria consumption and abundant small copepods at the 50–200‐m layer in 2014 and 2016. Starting from 4.88 μmol/(m2 day), summer average DMS fluxes increased sharply by threefold to fivefold in response to a warming of 2.8 °C in the surface water during 2012–2016.