No abstract

A series of 1,4‐N,N′‐bis‐substituted 1,2,4‐triazolium bromide salts were synthesized and tested for anti‐proliferative activity. 1,4‐Bis(naphthalen‐2‐ylmethyl)‐1,2,4‐triazolium bromide (2) showed activity against MDA‐MB‐468 breast cancer and PC‐3 prostate cancer cell lines.

A series of N,N′‐bis‐substituted triazolium salts have been synthesized using 1H‐1,2,4‐triazole, 1H‐1,2,3‐triazole, and 1H‐1,2,3‐benzotriazole. Synthesized compounds were tested for their antimicrobial activities against a panel of representative ESKAPE pathogens, which are common culprits of hospital‐acquired bacterial infections. Compounds 7 and 12 displayed significant antimicrobial activities against all pathogens including a vancomycin‐resistant strain of Enterococcus faecium and a multidrug resistant strain of Acinetobacter baumannii. Furthermore, the structure activity relationship of N,N′‐bis‐substituted triazolium salts revealed a potential selectivity of gram‐positive or gram‐negative bacteria based on the heterocycle center. Thus, N,N′‐bis‐substituted triazolium salts exhibit potent antimicrobial properties against multiple ESKAPE bacterial pathogens which warrants a further investigation of their biological activities.

No abstract