Background: We previously identified a 12-microRNA (miRNA) panel

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Objective: To investigate the Psychological Adaptation Scale (PAS) of the main relatives and caregivers of patients after esophageal cancer surgery and analyze its influencing factors. Methods: From December 2019 to January 2021, 290 postoperative patients with esophageal cancer and their main relatives and caregivers from a tertiary A tumor hospital in Guangzhou were selected as the research objects using the convenience sampling method. The general information questionnaire and the Chinese version were used. Psychological Adaptation Level Scale (PAS) and Zarit Caregiver Burden Interview (ZBI) were investigated. Results: The PAS score of the main relatives and caregivers after esophageal cancer surgery was 45.00 (32.00, 67.00) points, the lowest score was 27.00 points, and the highest score was 80.00 points. The level of the caregiver's psychological adaptation is positively correlated with the caregiver's burden. The multiple stepwise regression analysis shows that the families per capita income, whether there is care experience and the caregiver's burden are the influencing factors of the caregiver's psychological adjustment level. Conclusion: The psychological adaptation level of the caregivers of the main relatives of patients after esophageal cancer surgery is obviously low. Medical staff should improve the psychological adaptation level of the caregivers in a targeted manner and take effective measures according to different influencing factors to improve the psychological state of the caregivers.