To investigate the effects of tegretol on oxidative stress, serum inflammatory factors, and left ventricular function in patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention (PCI), 70 AMI patients who received PCI in the emergency department of our hospital from January 2021 to December 2021 were collected. The patients in the control group were treated with aspirin, clopidogrel, and heparin sodium during the perioperative period, and the patients in the study group were treated with tegretol. The levels of oxidative stress, serum inflammatory factors, and left ventricular function index were compared between the two groups. The patients in the control group were treated with TT (( 12.00 ± 2.05 ) s), APTT (( 35.50 ± 4.19 ) s), PT (( 16.60 ± 1.58 ) s), TT (( 15.90 ± 2.14 ) s) APTT (( 30.40 ± 3.80 ) s), and PT (( 14.30 ± 1.45 ) s)) and were comparable ( P > 0.05 ), and the difference was statistically significant ( t = 8.210 , 4.600, 7.010, P < 0.001 ). There was no comparable difference in the level of oxidative stress index before treatment ( P > 0.05 ). After treatment, there was significant difference in MDA (( 14.53 ± 2.14 ) mmol/L), SOD (( 120.45 ± 8.17 ) U/L), MDA (( 11.15 ± 2.02 ) mmol/L), and SOD (( 129.86 ± 8.55 ) U/L) in the control group ( t = 7.320 , 5.099, P < 0.001 ). The levels of inflammatory factors in patients before treatment were not comparable ( P > 0.05 ). After treatment, there were levels of IL-6 (( 3.20 ± 1.05 ) ng/L), CRP (( 4.80 ± 1.16 ) mg/L), MPO (( 196.78 ± 21.51 ) mg/L) and TNF-α (( 3.96 ± 0.80 ) pmol/L), IL-6 (( 1.95 ± 0.80 ) ng/L), CRP (( 3.10 ± 1.02 ) mg/L), MPO (( 163.60 ± 21.10 ) mg/L), and TNF-α in a study group level (( 3.05 ± 0.70 ) pmol/L), with statistically significant difference ( t = 5.187 , 6.028, 6.031, 4.689, P < 0.001 ). Before treatment, there was no comparable difference in the level of left ventricular function index ( P > 0.05 ). After treatment, there was significant difference in LVEF ((46.10 ± 2.39) %) and LVDD ((52.06 ± 1.07) mm), LVEF ((56.85 ± 2.33) %), and LVDD ((48.75 ± 1.02) mm) in the control group ( t = 17.640 , 21.540, P < 0.001 ). Tegretol as an adjunctive therapy for emergency PCI patients with acute myocardial infarction can effectively improve postoperative coagulation function, reduce oxidative stress and inflammatory reaction, and improve cardiac function indicators. It has a positive clinical value.

ObjectiveBenign paroxysmal positional vertigo (BPPV) is the most frequently diagnosed type of peripheral vestibular vertigo. Studies have reported a possible association between BPPV and osteoporosis; however, there is still a lack of evidence. This study aimed to investigate the characteristics of bone mineral density (BMD) and bithermal caloric test results in patients with unilateral posterior canal idiopathic benign paroxysmal positional vertigo (pc-iBPPV).MethodsBMD was measured in 65pc-iBPPV menopausal female patients and 65 healthy controls using dual-energy xray absorptiometry and then compared the T-score of BMD between the two groups. The bithermal caloric test was also performed with video nystagmography and the relationship between canal paresis, directional preponderance, T-score, and recurrence were analyzed.ResultsLower T-scores were observed in pc-iBPPV patients compared with the normal subjects. Among 65 pc-iBPPV patients, free recurrence was observed in 38 (58.5%), single recurrence was noted in 14 (21.5%), and multiple recurrences were seen in 13 (20%) patients. The proportion of positive T-score and CP value increased with the pc-BPPV recurrence frequency. Statistically, a significant difference was found only in T-score, indicating that recurrence was raised with a decrement of T-score. The proportion of positive CP values tended to increase as BMD decreased.ConclusionThe decrement of BMD might be one of the pathogeneses in patients with unilateral pc-iBPPV and associated with multiple recurrences. Moreover, positive CP value cannot be regarded as a predictive factor for recurrence; however, there is a clear association between CP and BMD.