therapy recommended by the World Health Organization (WHO) helps improve the chronic pain in over 80% of cases (3). However, the therapy is still to do not relieve pain in 15-20% of cases due to drug tolerance or serious adverse events. To make up for the shortcomings of three-step analgesic ladder therapy, the novel, a fourth step, including several therapies, was put forward (4), of which intrathecal drug infusion was most discussed.
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