The flavin-dependent monooxygenase AzmF catalyses posttranslational oxime formation during biosynthesis of the azolemycin complex of novel ribosomal peptide natural products.

The first total syntheses of newly isolated polyazole natural products azolemycins A-D, along with the synthesis of the tetra-oxazole non-natural analogue, are described.

The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross‐couplings and an enantioselective Kiyooka aldol reaction.