Reflection Seismology technique (Seismic Survey) is widely used around the world to produce a detailed analogue image of subsurface geological structures. This information is used by petroleum experts to accurately plan the location of oil wells. Seismic survey sections and corresponding well logs exhibit different variables like acoustic impedance of rock, seismic velocity, rock density, porosity, time and depth that can be manipulated in GIS to infer a subsurface model for stratigraphic as well as structural interpretations. In recent years, GIS has emerged as a powerful analytical tool for subsurface mapping and analysis. Petroleum exploration is a map intensive process that requires the powerful capabilities of GIS. Purpose of this research is integration of Geographical Information System with Seismic Surveys for Structural and Stratigraphic Interpretation of subsurface Geology and locating Petroleum Prospects. In this research work, GIS has been used to investigate subsurface geological structures and stratigraphy to carefully analyze the capabilities of GIS for finding new petroleum prospects in active thrust belt of Meyal, Potwar region, Pakistan. Acquisition of two-dip and three-strike seismic lines is along with well log data, followed by spatial seismic data processing, development of geophysical data management interface, interpolation of shot point data, trend surface analysis and Geostatistical analysis using GIS. Subsurface zones of high, low or null probability of petroleum accumulation were then, mapped. Finally, GIS based maps were developed. Geospatial tomography GIS model inferred that study area is structurally deformed and exhibits excessive geological faults, and structural traps. With GIS-tomography interpretation of section 97-MYL-08, a potential oil bearing zone (popup anticline), bounded by two thrust faults was observed at almost 3.6 Km depth in Meyal area How to cite this paper: