Osteoporosis is systemic metabolic osteopathy; its topical characteristics are low bone mineral density (BMD), bone microstructure damage and increases the risk of fracture (Weitzmann & Pacifici, 2006). Although the incidence of osteoporosis is high and steadily raising (Sotorník, 2016), its pathogenesis remains largely unknown.The maintenance of bone mass depends not only on the absorption function of osteoclasts and the osteoblast function, but also on the difference between the production rate and apoptosis rate of osteoblasts and osteoclasts. Among them, osteoblasts play a crucial role in maintaining bone homeostasis and can regulate the mineralization of the cytoplasmic matrix and control bone remodeling and osteoclast differentiation (Shang, 2019). The apoptosis of osteoblasts