Objective: This study aims to investigate the clinical presentation, frequency and histopathology of hydatidiform mole, as well as to determine the clinical significance of such histopathological examination. Material and method: This was a retrospective study undertaken at the Department of Pathology Bmsi Jpmc Karachi from January 1st, 2016 to November 31st, 2021.All molar pregnancy cases were thoroughly examined, taking into account their age, gestational age, signs and symptoms, clinical diagnosis where available and histopathology. Results: Total 73 cases of hydatidiform moles were obtained during study period. There were 64.3% partial hydatidiform moles and 35.6 % complete moles. The majority of the patients were between the ages of 21 and 35 years. Bleeding per vaginum was the most prevalent presenting symptom. The period of gestation in majority of patients (54.7%) was 2–5 months. Conclusion: We came to the conclusion that partial mole was more common than complete mole .Histopathlogical findings of PHM differ from CHM.The diagnosis of molar pregnancy is helped by histopathological study of products of conception (POC), that can be missed on clinical and ultrasound assessment. As a result, products of conception should be subjected to histological investigation on a regular basis to avoid missing the diagnosis of molar pregnancy. Keywords: Molar pregnancy,Trophoblastic hyperplasia, Hydatidiform mole,

Background: Tubercular lymphadenitis is one of the most common causes of lymph node enlargement in developing countries. Fine needle aspiration cytology is a simple cost-effective, Rapid and reliable technique and first line investigation for diagnosis of superficial and deep lesion. Aim and objective: of our study was to evaluate the common cytomorphological pattern of lymph node swelling in pathology department of BMSI, Jinnah post graduate medical centre Karachi. Materials and methods: Cross sectional study was conducted at BMSI, Jinnah Post Graduate Institute Karachi. During the period of January to December, 2021, total 350 lymph node swelling were aspirated smear and cell block prepared Aspiration done with 22 to 24 needle gauge syringe.one slide is stained with the diff quick stain and evaluated for diagnostic material inadequate materials were re-aspirated at the time of FNA, three slides were stained with heamotoxylin and eosin stain. Cell block prepared. Results: Total 350 lymph node swelling were aspirated during study time out of which 203(58%) cases diagnosed as chronic granulomatous inflammation, 43(12.3%) cases diagnosed as necrotizing inflammation. 37(10.6%) case diagnosed as abscess and 22(6.3%) cases as reactive hyperplasia, 39(11.1%) cases as metastatic lesions. Conclusion: Chronic granulomatous inflammation is a heavy burden of lymphadenopathy in our setup followed by necrotizing inflammation Keywords: BMSI FNA granulomatous inflammation