No abstract

A FeCl 3 -promoted synthesis of spiro[4.5]decane derivatives has been developed from 2-(5,5-dimethoxypentyl)-1-substituted cyclopentanols with high diastereoselectivity. These interesting compounds are formed through a cascade process involving a FeCl 3 -promoted dehydration of alcohol followed by FeCl 3 -mediated Prins cyclization.

FeCl 3 -Promoted One-Step Synthesis of Spiro[4.5]decane Derivatives. -Dehydration of various cyclopentanol substrates followed by Prins cyclization affords the desired structural units with a high level of diastereoselectivity. -(ZHENG, D.; MA, Z.; GONG, W.; XIE*

Unexpected Prins Cyclization: Iron-Promoted Cyclization/Hydration of Alkynyl--Dimethyl Acetals. -A novel strategy for the preparation of acyl substituted cycloheptenes is developed using an intramolecular Prins cyclization in the presence of FeCl3 as reagent. -(ZHENG, D.; GONG, W.; MA, Z.; MA, B.; ZHAO, X.; XIE*, Z.; LI, Y.; Tetrahedron Lett. 52 (2011) 2, 314-317, http://dx.