Cardiomyopathies (CMP) are considered diseases with unknown etiology. CMP are usually diagnosed on the late stages of the disease. It is an important task to seek methods which allow diagnosing CMP on the early stages of development. Aim -to estimate the type of polymorphic variants of angiotensin converting enzyme (ACE), glutathione S-transferase (GSTM1) frequency distribution among the CMP sick and healthy individuals living in the Republic of Bashkortostan, and to substantiate their role in the CMP pathogenesis. Material and Methods -There were 67 CMP sick put under observation. Out of them40 werediagnosed ischemic cardiomyopathy (ICM), and 27 were diagnosed dilated cardiomyopathy (DCM). The control group was made up of 110 practically healthy people. The results.In the ICM sick group the DD genotype (χ 2 =4.8; p=0.029) was definitely found more frequently, also in case of DCM the increase of DD genotype (χ 2 =4.0, p=0.044) frequency was ascertained. Conclusion -The genetic analysis of polymorphic locus of I/D ACE gene in the ICM and DCM sick showed decrease in frequency of occurrence II, ID genotypes, I allele and increase of D genotype and D allele which points out the increased risk of these cardiovascular diseases.

The results of a comprehensive examination and treatment of a patient with new coronavirus infection COVID-19 showed the possibility of the patient recovering without the use of certain groups of drugs used to treat this disease in accordance with temporary guidelines at the time of the analysis of the clinical case. There is an attempt to define the role of the close ones and their presence at all stages of the treatment in a favorable outcome. Most people want to take care of a relative having a severe form of the disease. Thus, it is necessary to develop an algorithm for visiting the patient by near relations in the hospital. The course of the new coronavirus infection in a particular case, the psychological state of the patient's relatives, the fear of prescribing or not prescribing certain drugs, the fear of bringing a loved one to the "point of no return" are analyzed.

The article is a review of the literature, which deals with the classifi cation, etiology, pathogenesis and risk factors of cardiomyopathies, analyzes the results of diagnostics with the use of modern technologies. The presence of cardiomyopathy always means a diffi cult life prognosis in patients. It determines the social signifi cance of the problem connected with this pathology, which is the cause of disability and mortality of most active working age patients.

Целью работы явилась оценка содержания и значения провоспалительных цитокинов ИЛ8, ФНОα, МСР1, противовоспалительного цитокина ИЛ10 при ХСН у больных с дилатационной и ишемической кардиомиопатией. При изучении содержания провоспалительных цитокинов, моноцитарного воспалительного белка хемокина МСР1 и провоспалительного хемокина выявлено достоверное разнонаправленное изменение уровня провоспалительных цитокинов (снижение ИЛ8, рост ФНОα) и хемокина МСР1 при дилатационной и ишемической кардиомиопатией и увеличение концентрации провоспалительного хемокина ИЛ10.

No abstract