The article substantiates the need of creation a potato cluster in the Voronezh region for sustainable development of the potato industry. The strategic parameters of the development of the potato industry in the region are determined in a multivariate performance. The results of applying the economic-mathematical model to optimize the sectoral structure of the agricultural sector of the region are estimated. Bringing the sectoral structure of production in the region to the optimal will increase potato production by 40 centners from 100 hectares of arable land, as well as increase profitability to 11.5 %, revenue per 100 hectares of farmland by 401 thousand rubles, and profit per 100 hectares of farmland by 57 thousand rubles.