ДвНЗ «Івано-Франківський національний медичний університет» Мета дослідження: оцінювання діагностичного і прогностичного значення визначення С-реактивного білка (СРБ) у крові та еякуляті хворих на хронічний бактеріальний простатит (ХБП) і можливість використання цього тесту для моніторингу перебігу захворювання. Матеріали та методи. Обстежено 65 хворих на ХБП віком від 20 до 50 років (основна група) і 25 здорових чоловіків аналогічного віку (контрольна група). Результати. У сироватці крові хворих на ХБП при зверненні реєстрували підвищення рівня СРБ, практично у всіх хворих він досягав «гострозапального» діапазону і становив у середньому 14,82±3,28 мг/л. Одночасне визначення СРБ в еякуляті хворих на ХБП у стадії загострення виявило концентрації біомаркера, що у 4,3 разу перевищували показники в крові і становили у середньому 64,32±4,46 мг/л. Заключення. У хворих на хронічний бактеріальний простатит при загостренні захворювання виявлено значне підвищення С-реактивного білка в еякуляті, яке в декілька разів перевищувало його вміст у сироватці крові, що дозволило припустити можливість локального синтезу біомаркера при ураженні передміхурової залози. Ключові слова: хронічний бактеріальний простатит, С-реактивний білок.
Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica, subspecies enterica, serotype Typhi, which is mostly contracted through the ingestion of food or water contaminated by the faeces of an infected person. Serum sodium, potassium, chloride, and bicarbonate levels were determined in sixty patients with established typhoid fever attending General Hospital Minna, using Spectrophotometric method. The case studies included 15 adult-males, 15 adult-females, 15 male-children, and 15 female-children. The mean ± standard deviation of serum Na + , K + , Cl-, and HCO 3 2in the sixty patients were 116.11 ± 20.65mmol/L; 3.40 ± 0.90mmol/L; 87.13 ± 16.34mmol/L; and 24.10 ± 5.54 mmol/L respectively. When compared with the controls and the laboratory reported normal values, 50% of the patients were found to be hyponatraemic, 51% were hypochloraemic, 36% were hypokalaemic, while 11% had metabolic acidosis. Results based on sex showed insignificant difference between males and females for all electrolytes determined (p< 0.05). An insignificant difference was also observed between children and adult patients for all parameters determined (p< 0.05). In addition, weak positive correlations were observed between cations and anions determined in this study. The results obtained in this study showed that electrolytes abnormalities existed in patients with established typhoid fever attending General Hospital Minna,
According to the data more of urologists 9–35% men suffers from a c chronic prostatitis. Near 80% work out men for 20 to 50 years old. Lately events of chronic prostatitis increase because also increases different forms of uretritis, epydidimoorchitis, lowering of the resistance of organism and the influence of outside environment.The objective: of our study was to conduct a comparative analysis of the normal contents and bacterial prostatitis (BP) macro– and traceelement composition of blood to optimize the regeneration of the processes.Materials and methods. The study involved 65 patients with bacterial prostatitis aged from 18 to 48 years, who were divided into groups: Group І patients with BP, group ІІ – control group, consisted of 25 healthy persons with patients of similar age. Determination of serum microelements was carried out by atomic absorption spectrophotometry. Statistical analysis of the results of research was carried out by using a standard computer program Microsoft Excel.Results. Thus, the determination of Zinc in blood showed that in general patients with BP observed a significant reduction of trace elements such as Zinc content was (0,48±0,02) mg% and differed significantly from that seen in healthy persons (P<0,001). This result is quite significant, since it is known that Zinc deficiency is associated with reduced antioxidant enzyme systems and formation of adequate response of the body to the action of bacterial agents in BP.Conclusions. The presence of an imbalance in the system ofbioele ments is one of the pathogenetic mechanisms of development and progress ofinflammation in patients with bacterial prostatitis. Clinical implementation of metabolic disorders occurs at the level of the element with the violation of immunological resistance of the organism.
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