Проведено сопоставление биохимических показателей основных обменных процессов и функций печени в подгруппах больных описторхозом, вызванным Opisthorchis felineus, с наличием и отсутствием мутаций в локусах, ассоциированных с предрасположенностью к остеопорозу.

The aim of the study was to identify a relationship between polymorphisms associated with developing coronary heart disease and pathogenetic features of opisthorchiasis invasion. Laboratory parameters of immune system functioning (lymphocyte phenotypes assessed by flow cytometry, immunoglobulin and cytokine level, non-specific resistance indices) in patients with chronic opisthorchiasis (caused by Opisthorchis felineus) with various genotypes – with/without mutations in loci associated with predisposition to developing coronary heart disease – were compared. It was found that in case of mutated adenosine monophosphate deaminase 1, hypoxia-inducible factor 1 alpha, apolipoprotein E vs. no minor alleles, an effect of opisthorchiasis invasion altered immune response.Moreover, patients with mutated adenosine monophosphate deaminase 1 gene had lowered adaptive cellular immunity (reduced count of cytotoxic lymphocytes), adaptive humoral immunity (reduced level of immunoglobulin A). Patients with opisthorchiasis bearing rare allele in the hypoxia-inducible factor-1 alpha, activation of adaptive immunity and decreased activation of innate immunity were identified. Mutation in the apolipoprotein E gene leads to decreased activity of adaptive cellular immune response, which exacerbates course of opisthorchiasis invasion. Moreover, minor allele of the rs1333049 polymorphism in cyclin-dependent kinase inhibitor gene did not lead to marked changes in host immune response. Thus, in case of mutations resulting in impaired function in some proteins, an effect of opisthorchiasis invasion leads to multidirectional changes in parameters of immune response, whereas normalizing parameters bound to diverse arms of immune system in the presence of chronic parasitic invasion may not always be interpreted as a “protective” effect posed by carriage of any gene polymorphism. Peak changes in the immune response in patients with chronic opisthorchiasis were detected in the presence of polymorphism in the hypoxia-inducible factor-1 alpha gene. The results obtained suggest that such genetic polymorphisms may be involved in predisposition to manifestation of some opisthorchiasis clinical forms.