The article is devoted to the peculiarities of the married couples whose infertility was caused by male factor. There were analyzed 420 cases applied for auxiliary reproductive technologies (ART) at the Institute of Reproductive Medicine (Kyiv), where 140 couples used the method of male sperm insemination, 180 – intracytoplasmatic spermatozoa injection and 100 – intracytoplasmatic injection of morphologically selected spermatozoa. It was noted that with the patient’s age increase, more complicated reproductive technologies are used. In all cases the women were younger, but only after 40 years the difference with a male age is reliable. For the >1 – < 5 years period an absence of native pregnancy shows the main bulk of references (65.5%) to ART. There were revealed preconditions of male infertility, formed into factors, their signs, with assessment of informative value. It was proved that with the increase of aggravating circumstances, the ART complicacy also grows. The received data are of interest in plane of improvement of prophylactics, informative enlightenment, possession of information about ART.

The work presents the analysis of the effective method for intracystoplasmic sperm injection (ICSI) in the extra corporal fertilization. The study included 180 couples with male infertility factor who had received medical aid in the Institute of Reproductive Medicine (Kyiv) during 2013–2015. The diagnoses were verified, the patients were examined in accordance with the clinical protocols. The ICSI procedure was performed by the common methods. Before the start, the women underwent the course of controlled ovarian stimulation according to the well known classic protocol. The received data were considered taking into account the type of pathospermia (oligoasthenozoospermia, obstructive and non1obstructive azoospermia). As a result of two cycles, the biochemical pregnancy was noted in 97 out of 180 couples (53,9%). But, after the reproductive losses which were the highest between men with non1obstructive azoospermia (14,3% versus 4,5%), the child birth reached 92 (51,1±3,7%), along with group with oligoasthenozoospermia – in 65 out of 120 (54,2±4,5%), obstructive azoospermia in 2out of 38 (55,3±7,5%), non1obstructive – in 6 out of 22 (27,3±9,0%); the last value was statistically less. This information testifies to the necessity to look for the elevation of the ICSI effectiveness. Nowadays, the most actual in this aspect is considered the improvement of selection criteria for including into the program, with this – the decisive importance belongs to the study of risk factors spectrum which would assure the personified approach to solve the problem.

The objective: the rationalization of a personalized approach to the selection of the program art on the basis of the allocation of risk. Patients and methods. Were analyzed 180 couples with male factor infertility, which in 2012-2015, in the Institute of reproductive medicine (IRM) (Kiev) was held the program of intracytoplasmic sperm injection (ICSI) with the aim of restoring fertility. Examination and ICSI procedure is carried out in accordance with clinical protocols. Results. According to the results of analytical and synthetic analysis of primary documents (enhanced, adapted to the purpose of the work of the medical record) were identified risk factors (and their signs) for the development of male infertility and grouped by direction of impact. As a result, 25 of the 51 factors and their basis formed three groups: social (behavioral), biological/clinical and special medical. With the help of mathematical analysis it was determined the boundary values of the minimum and maximum of reliability of the negative result of the application of ART. Conclusion. It was proposed the predictive map for the determination of the probability of pregnancy in couples with male infertility problems with the application of ART. Was justified the separation of three risk groups to restore fertility in couples with male factor infertility using ART. Was based the principle of personalized approach to choosing the best program of art-based stratification of men at risk groups. Key words: male infertility, assisted reproductive technologies, risk factors, prognostic chart.

The work represents the results of analysis of spermograms in men with infertility of 420 married couples who referred during 2013–2015 to the Institute of Reproductive Medicine (Kyiv) for fertilization with the aim to restore fertility. There were revealed the parameters of dependence of the used programs of the assisted reproductive technologies. Based on the quantitative assessment in scores, the most informative significant spermograms, determining the choice of technology, were selected.

The paper analized the results of reproductive function restoration in 140 married couples with male infertility, which passed the program of insemination with man’s sperm in 2013–2015 at the Institute of Reproductive Medicine (Kyiv). It was found that the number of pregnancies and childbirths after 3 attemps (420 cycles) with an interval of 3–5 months was reached in 17,0±1,8% and 15,0±1,8% cases, respectively. The presence of a linear relationship between the fact of fertility recovery and factors such as the woman’s age, duration of non-set of natural pregnancy, and the response of the ovulatory function to stimulation was confirmed. The influence of the spermogram indicators on the result is objectified: the type of pathospermia, the concentration of sperm, which is inversely dependent on the presence of predictors and determinants that burden the general condition of the man, as well as the percentage of actively moving sperm fractions.