The article presents the results of experimental research on monofilament suture with different biodegradation periods when implanted into trachea tissue. The data obtained via histological, morphological and morphometric methods have been shown that application of monofilament suture material with long biodegradation period causes evident inflammatory reaction of trachea tissue, which persists through the entire period of monitoring, by 30th day the cell index value is 0.4±0.05. Unlike monofilament non-absorbable suture and suture with short biodegradation period, the application of which is marked with active proliferative process on the 14th day, the cell index is equal to 0,9±0.05 and 1,1±0,06 respectively. The obtained data demonstrate that application of monofilament suture material with long-term biodegradation period in tracheal surgery is non-desirable as the inflammatory process maintained by the suture material under conditions of high contamination by bacteria and active process of mucus formation will adversely affect healing. Application of suture with short-term biodegradation period in acute trachea injury treatment is optimal due to the fact that the organ tissue shows minimal reaction to suture and 60 days later the suture is completely absorbed, that means will not cause further complications.

The article is devoted to the study of the problem of myometrium reaction on implantation of polypropylene mesh prostheses in uterine suture strengthening. Experimental studies have found in animals after strengthening the seam on the uterus polypropylene mesh implant following complications in the postoperative period, such as: bruises, seroma seam and deformation of the uterus. These complications occurred significantly more often than when suturing the incision of the uterus row of blanket stitch. In the evaluation of adhesions, the statistically significant differences in the studied groups weren´t found. According to morphological studies, it was revealed in the early days a tissue edema and infiltration by plasma cells and macrophages, which remained at a later time, a capsule isn´t fully formed, cellular component prevailed over fiber. In later terms a mature fibrous capsule is formed, necrosis areas are detected on the inner side of prosthesis filaments, giant cells of foreign bodies, neutrophils, eosinophils were found around filaments. To objective evaluation of the state of inflammatory process around prosthesis filaments the authors used a cellular index method. It was determined that the degree of spatial organization of the capsule and the degree of maturity of the connective tissue is in direct proportion to the duration of the experiment.