Objective: To study the therapeutic effects of mexidol, hyperbaric oxygenation and timogena in complex treatment of patients with neurotic personality development and its impact on quality of life of patients. Material and methods: The study included 142 patients with neurotic personality development. Patients of the first group were prescribed conventional therapy anxiolytic and antidepressant within 30 days. Patients of the second group were treated basic therapy and antioxidant immune correctors, sessions of hyperbaric oxygenation. Performance criteria for the final evaluation of the results of treatment were: reduction of the severity of psychiatric symptoms, improve mental and physical performance and social activity. Results: In patients with neurotic personality development identified physical and mental exhaustion, re-duced intentions, low productivity at work and social exclusion, which is reflected in low rates of quality of life in social relations and in the psychological realm. These symptoms on a background of traditional anxiolytic and antidepressant therapy didn’t cropped, but compounded undesirable actions of these drugs. Combined anxiolytic and antidepressant combination with hyperbaric oxygenation and antioxidant immune correctors demonstrate the effectiveness of the therapeutic effects of metabolic therapy, which is manifested in a significant improvement in physical, mental and social functioning of patients and improve their quality of life. Conclusions: The combination of paroxetine and diazepam with mexidol, hyperbaric oxygenation therapy, timogena can reduce the undesirable effects of antidepressants and benzodiazepine anxiolytics, increase efficiency of patients, their activity in communication, social inclusion and quality of life, indicating that the high efficacy and safety of this regimen.