A Quantitative Structure-Activity Relationship (QSAR) study has been carried out for 27 flavonoids belonging to four different groups (isoflavons, flavons, flavonols, flavanons) to correlate and predict the inhibition of lipids peroxidation effects (antioxidant activity). The genetic algorithm (GA) and multiple linear regression analysis (MLRA) were used to select the descriptors and to generate the correlation models that relate the structural features to the biological activities. ) values and scrambling/randomization experiments also confirms the statistical significance of our models. These models are expected to be useful for screening of flavonoid antioxidants.

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