15. Yiang Y. [Rubella virus RNA replication is cis-preferential and synthesis of negative-and positive-strand. RNA is regulated by the processing of nonstructural protein] / Y.

No abstract

The article presents a comparative analysis of clinical manifestations, diagnostics, therapy and outcomes of a new coronavirus infection in children of Khabarovsk who were and are in non-hospital and hospital observation settings. The substantiation of the therapy with interferon preparations eff ectiveness is given on the basis of the obtained changes in the parameters of interferon alpha, interferon gamma and interleukin-6, depending on the clinical form of infection -ARVI and pneumonia.

The research presents results of the analysis by polymerase chain reaction of clinical material obtained from 170 children hospitalized into an infectious department of the Khabarovsk children’s territorial clinical hospital named after A.K.Piotrovich with a diagnosis of acute viral infection in epidemic season of 2015-2016. The most numerous group consisted of children under 1st year of age – 74 children (43.5%). The overall number of detected respiratory viruses was equal to 179. Most prevalent viruses were human rhinoviruses (25.1%), human adenoviruses (19.6%), and human parainfluenza viruses (16.8%). Among influenza viruses (11.7%) type A(H1N1) pdm09 was predominant. In 92 children (54.1%) the disease was caused by a mono-infection, in 40 cases (23.5%) there was identified mixed-infection. Infections of lower respiratory tract were identified in 100 patients (58.8%), stenosing laryngotracheitis was diagnosed most frequently (20.6%).