Different surfaces were obtained by Plasma Electrolytic Oxidation (PEO) of the Ti-6Al-4V alloy; followed by hydrothermal treatment (HT). The surfaces were studied by scanning electron microscopy (SEM); Energy Dispersive Spectroscopy (EDS); X-ray Diffraction (XRD); Brunauer-Emmett-Teller (BET) absorption and abrasion wear tests. The resulting surface contains hydroxyapatite (HA); which contributes to superior implant osseointegration. Treated implants were introduced into rabbits and their osseointegration was studied after two and six months. It was established that implant surface area increases due to pore formation. Pore formation and hydroxyapatite on the surface of the implant qualitatively change contact osseogenesis processes with reduced duration of osseointegration of implants. The treatment of the surface of the implants by the combination of PEO and HT provided better results in the medico-biological investigations than PEO alone. Abrasion tests demonstrated that the HA will be preserved after the procedure of implantation; ensuring effective osseointegration.

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The acquired defects of the top jaw owing to injuries or surgeries concerning new growths, in most cases lead to violations of functional and esthetic character. Rational prosthetics of this category ofpatients is important in a complex of rehabilitation actions. The greatest difficulty in orthopedic treatment is presented by defects of the top jaw in the presence of the oro-nasal message. The purpose of work was improvement of quality of orthopedic treatment ofpatients with the acquired defects of the top jaw. In article use option for production of difficult and maxillary artificial limbs obturators of the polyamide constructional material reinforced by the nanomodified dioxide of the titan is considered. Production of difficult and maxillary artificial limbs according to indications from the polyamide material Vertex ThermoSens allows to enter an artificial limb into retentsionny zones, remote for rigid materials, that improves his fixing and obturiruyushchy characteristics, lack of metal elements of fixing considerably improves esthetic parameters of an artificial limb. There is technically easily feasible possibility ofproduction of the facilitated designs of difficult and maxillary artificial limbs, without loss of strength characteristics, due to reinforcing of basic material the nanostructured dioxide of the titan. As a result of rational prosthetics ofpatients with the acquired defects of the top jaw psychological and social rehabilitation is reached them.

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Subject. Changes in the activity of certain saliva enzymes, due to certain factors and in certain clinical conditions of the human body, can affect oral hygiene, as well as indirectly on the activity of the carious process. Of particular interest is the enzyme — alpha-amylase, which is due to its ability to cleave dextrans and levans, which are the basis of the matrix of the bacterial film. The article presents data on changes in the activity of saliva alpha-amylase in microecological disorders in the intestine and acute respiratory viral diseases, as well as its effect on the level of oral hygiene. The goal — the assessment of changes in the activity of saliva alpha-amylase in microecological disorders in the intestine and acute respiratory diseases, taking into account the level of oral hygiene. Methods. To determine the activity of alpha-amylase, a set of reagents "Amylase-Vital" was used according to the manufacturer's instructions, proportionally reducing the volume of reagents for the procedure in titration plates. The volunteers, divided into groups with severe acute respiratory syndrome, microecological intestinal disorders, and a control group, received mixed saliva and evaluated their oral hygiene status. Results. The inverse relationship between the severity of intoxication syndrome in severe acute respiratory syndrome and the level of saliva alpha-amylase activity is shown. In addition, a correlation was established between an increase in human body temperature and a decrease in the activity of alpha-amylase. There is also a link between the presence of decompensated intestinal dysbiosis in humans and the activity of the enzyme. The dependence between the decrease in the activity of the studied enzyme and the increase in biofilm formation on the organs of the oral cavity was revealed. Conclusions and Relevance. The conducted studies open up a promising direction for the development of additional diagnostic criteria based on the determination of the activity of saliva alpha-amylase. In addition, the data obtained on the deterioration of oral hygiene indicate the need for a comprehensive approach to the treatment of patients in this category with the mandatory involvement of a dentist.