Aim of the study is to develop the diagnostic checklist based on the incidence and significance analysis of the external features of the dysplasia of the connective tissue (DCT) for its screening and assessment of its prevalence in the adolescents' population. Materials and methods.110 adolescents (aged from 10 to 14 years) were examined, 81 of them had the dysplasia of the connective tissue (the first group). The second group was presented by 29 adolescents without DCT. The presence and degree of manifestation of DCT were established according to the criterions of Kadurina T. I., Gorbunova V.N. (2009), Т. Milkovska-Dimitrova (1987). There were the physical, laboratory and instrumental examination. Statistical processing of the results was carried out using Statistica 6.0 program and IBM SPSS

Development of the undifferentiated connective tissue dysplasia (UCTD) is influenced by various adverse factors to the fetus during intrauterine growth. There is not a clear linkage to the contribution of the separate factors to the development of the UCTD.Aims of the studyare to determine the risk factors associated with the development of the UCTD of the adolescents and to appreciate the predictive value of the examined factors related to UCTD to form the dispensary groups of the children with UCTD.Materials and methods. During the first stage of the study there was an examination of 110 adolescents at the age of 10–14 years old, the UCTD presence was established according to the scale proposed by T.I. Kadurina and V.N. Gorbunova (2009). During the second stage the data of the prenatal casework and maternity hospital records attached to the out-patient medical records were examined to detect the specialties of the antenatal life course. During the third stage 2 groups were formed: with the presence of UCTD (n = 81) and without UCTD (n = 29). The mother groups were formed accordingly with the adolescents groups.Results. The pregnancy of the mothers of the adolescents with UCTD proceeded against the anemia, threatening miscarriage, chronic fetal hypoxia, chronic fetoplacental insufficiency, toxicosis, gestosis, and concomitant chronic conditions (thyroid, kidneys, digestive apparatus, aspiration pathology) more common than the pregnancy of the mothers of the adolescents without UCTD. The binary logistic regression method allowed the predictors of the UCTD’s formation to be determined, there were: toxicosis during the gestation course (OR = 10.9; CI 95% 2.94–40.49), anemia of pregnancy (OR = 8.6; CI 95%: 2.42–30.81), gestosis (OR = 6.53; CI 95%: 1.27–33.71), chronic fetal hypoxia (OR = 4.4; CI 95%: 1.09–17.83) and pre-existing chronic conditions of the mothers (OR = 3.6; CI 95%: 0.86–15.48). Different factor combination enhances the likelihood of the delivery of a child with UCTD more than 6.5-fold: chronic conditions of the mothers and chronic fetal hypoxia (OR = 6.8; CI 95%: 1.95–48.57); anemia of pregnancy and chronic fetal hypoxia (OR = 7.2; CI 95%: 1.01–50.99), and toxicosis (OR = 10.4; CI 95%: 1.48–72.82).Conclusion. The risk factors associated to the development of UCTD in adolescents are: toxicosis during the gestation course, anemia of pregnancy, gestosis, chronic fetal hypoxia and pre-existing chronic conditions of the mothers. The use of the equation of the binary logistic regression allows the prediction of the possibility of the development of UCTD in adolescents at the level of 80.9% and to form the dispensary groups of children in order to prevent the development of dysplastic-dependent pathology

Early detection of the connective tissue dysplasia (CTD) is hampered as the used diagnostic criteria are complex and subjective. The aim of the study is to examine the incidence and clinical profile of the adolescent CTD by means of the screening checklist. Methods. The study included the pupils at the age of 10-14 years. The questionnaire designed to reveal the 7 CTD's signs (thin skin, skin hyperelasticity, keloid cicatrix, blue sclera, soft auricles, arachnodactylia, joints hypermobility), containing 12 illustrated questions with explanation for the parents, was performed as a screening method. The conditionally healthy group (the absence of CTD) consisted of the adolescents with below 12 points total and CTD group was presented by the adolescents with 13 and more points. The physical development was appreciated according to the centile tables, Quetelet index and Vargui index. The health status analysis was based on the outpatient medical records. Results. 1560 pupils were the participants of the study: 752 boys (48.2%) and 808 girls (51.8%). CTD signs were observed in 965 (61.9%) children. The adolescents with CTD's signs demonstrated the following characters more often than the adolescents without CTD's signs: soft auricles-788 (81.7%) against 277 (46.6%), skin hyperelasticity-685 (71%) against 93 (15.6%), joints hypermobility-665 (68.9%) against 203 (34.1%), blue sclera-665 (68.9%) against 184 (30.9%), arachnodactylia-534 (55.3%) against 57 (9.6%). The disharmonious physical development because of the underweight body took place in 430 (52.3%) adolescents with CTD. Compared to the conditionally healthy group the most of the adolescents with CTD had the pathology of the musculoskeletal system (scoliosis, flatfoot), myopia, vegetative-vascular dystonia, digestive apparatus diseases. The CTD is associated with greater probability of the development of above mentioned pathologies, that can be indicative of the contribution of the anomalies of the connective tissue development into the etiopathogenesis of the these diseases. Conclusion. It is established that there is the high prevalence of the CTD signs among the adolescents (pupils) at the age of 10-14 years.

Цель исследования. Оценка биологического возраста и темпа старения у пациенток с недифференцированной дисплазией соединитель-ной ткани. Материалы и методы. Определен биологический возраст по методике Войтенко В.П.-Токарь А.В.-Чеботарев Д.Ф. (1984г.) у 89 женщин, имеющих 6 и более фенов недифференцированной дисплазии соединительной ткани, и у контрольной группы женщин (n=42), имеющих менее 6 фенов недифференцированной дисплазии соединительной ткани. Внешние фенотипические признаки недифференци-рованной дисплазии соединительной ткани оценивались в процессе общего осмотра, антропометрии, УЗИ сердца, органов брюшной по-лости на аппарате «Hitachi F37». После вычисления биологического возраста, определяли должный биологический возраст по формуле: дБВ = 0,581хКВ+17,24, где КВ-календарный возраст. На основе коэффициента скорости старения (КСС = БВ/должный БВ), определяли, во сколько раз биологический возраста обследуемой больше или меньше, чем должный биологический возраст ее сверстниц. Результа-ты. У пациенток основной группы выявлен разрыв (около 8 лет) между календарным и биологическим возрастом, положительная разница между биологическим возрастом и должным биологическим возрастом, а также коэффициент скорости старения >1. Выводы. У пациенток с недифференцированной дисплазией соединительной ткани происходит ускорение течения механизмов старения. Ключевые слова: биологический возраст, преждевременное старение, недифференцированная дисплазия соединительной ткани Для цитирования: Кононова Н.Ю., Чернышова Т.Е., Загртдинова Р.М. ОЦЕНКА БИОЛОГИЧЕСКОГО ВОЗРАСТА И ТЕМПА СТАРЕНИЯ У ПА-ЦИЕНТОК С НЕДИФФЕРЕНЦИРОВАННОЙ ДИСПЛАЗИЕЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ. Архивъ внутренней медицины. 2017; 7(4): 287-291. Abstract Aim. Assessment of biological age and the rate of aging of patients with undifferentiated connective tissue dysplasia. Materials and methods. 89 women with 6 or more undifferentiated connective tissue dysplasia phenes and 42 women of the control group with less than 6 undifferentiated connective tissue dysplasia phenes had their biological age determined using the method of V.P. Voitenko.-Tokar A.V.-Chebotarev D.F. (year 1984). External phenotypic signs of undifferentiated connective tissue dysplasia were evaluated during general examination, anthropometry, heart and abdominal organs ultrasonography using «Hitachi F37» device. After calculating biological age, expected biological age was determined using the following formula: eBA = 0,581хCA+17,24 where CA is calendar age. Then the aging rate coefficient was defined (ARC = BA/eBA), which illustrates the number of times the biological age of the examinee is greater or less than expected biological age of her peers. Results. Patients of the main group had a gap (about 8 years) between calendar age and biological age, a positive difference between biological age and expected biological age, as well as aging rate coefficient > 1. Conclusions. Women with undifferentiated connective tissue dysplasia have accelerated aging mechanisms.