Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского, г. Москва Проведено обследование мазков отпечатков 79 погибших плодов, выкидышей, новорожденных с аномалиями развития и признаками внутриутробной инфекции с целью определения частоты инфицирования герпетическими вирусами: вирусом герпеса человека 6 типа (ВГЧ-6), цитомегаловирусом (ЦМВ), Эпштейна-Барр вирусом (ВЭБ) и вирусом краснухи, выяснения особенностей течения анте-и неонатального периода, причин развития летального исхода, определения гистологических маркеров внутриутробной инфекции. Ключевые слова: новорожденный, внутриутробная инфекция, неонатальный период, герпетические вирусы, вирус краснухи, реакция непрямой иммунофлюоресценции (РНИФ). Epstein-Barr virus (EBV) and rubella virus clarify features of current ante-and neonatal period, causes of death, the definition of histological markers of intrauterine infection.

The paper presents data on the detection and role of cytomegalovirus infection (CMVI) in 146 children of certain groups aged from 3 months to 15 years who were hospitalized — frequently ill children with respiratory pathology, patients with shiga-toxin-associated hemolytic uremic syndrome (STEC-HUS) and schoolchildren with somatic diseases during rehabilitation in a sanatorium.The aim of the study was to determine the frequency of detection of CMVI in the presented groups, the originality of the main clinical manifestations in correlation with the markers of activity of herpesvirus type V infection. Clinical monitoring was carried out, oropharyngeal swabs, saliva,blood samples (serum and blood cells) were studied using a set of laboratory diagnostic methods:RCM (rapid culture method) on Vero- and M-19 cells, IIR (reaction of indirect immunofluorescence), ELISA to detect specific antigens and antibodies (IgM, IgG).The detection rate of CMV IgG in diagnostic values ranged from 6.4% in the group of frequently ill children with respiratory pathology to 31.7% in schoolchildren of the sanatorium, the acute course of infection was detected in3.2% and 6.4%, respectively, based on markers of acute infection (CMV IgM and cytomegalovirus antigen). In patients with STEC-HUS CMV IgG in diagnostic titers were recorded with the highest frequency — in 74.4% of patients.