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The objective: to evaluate effectiveness of complex treatment of dyshormonal breast diseases with mastodynia in reproductive age women. Patients and methods. 82 women aged from 23 to 45 years with dyshormonal breast diseases (DBD) accompanied with mastodynia took part in the trial. Diagnosis has been verified based on the patients ‘complaints, clinical observation of mammary glands, instrumental, clinic and laboratory investigation methods (ultra sound examination, aspirational biopsy, bilateral mammography). Assessment of mastodynia severity conducted using visual analogue pain scale (VAPS) in points. Diagnostic of anxiety level among examined women carried out by using Spielberg – Hanin methodology. All patients got Vitokan (Fita®) 30 drops 3 times per day 20–30 min before meals in combination with local transdermal gel contained 1% of micronized progesterone - Progestogel® (Besins Healthcare). Treatment duration was 3 months. Patients’ examination conducted in 1–3–6 months. Results. According to the Medical Center data, it was observed that diffuse dyshormonal breast diseases occupied leading positions among all breast pathologies reaching 45–47% share. All women included in the trial had complaints on cycle bilateral breast pain (mastodynia) which appeared 8–10–12 days before menses. Diffuse seals and tenderness have been discovered via palpation. Diffuse fibrocystic hyperplasia with dominated cystic component was found in 47.6% of women and was recognized as most frequent pathology based on the results of ultra-sound breast examination. Combined treatment of Progestogel® and Vitokan leads to reduction of mastodynia symptoms in 76.8% women after the 1st month of treatment/dynamic observation and in 95% of women after the next 3 months. It was shown statistically significant decrease in the level of situational anxiety after conducted treatment that led to improvement in mood. Conducted trial defined women’s subjective evaluation based on their complaints as the key factor of treatment effectiveness All objective methods of patient’s examination have secondary importance. Conclusions. High effectiveness of Progestogel® and Vitokan combined therapy has positive impact on clinical presentation, psycho-emotional condition (decreased level of anxiety) and proved by objective and instrumental methods of examination with no side effects. This fact provides evidence for using proposed combination for treatment of dishormonal breast diseases. Key words: dishormonal breast disease, mastodynia, treatment, herbal medicine, progesterone, Prozhestozhel, Vitokan.

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