Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene. Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev. Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods. Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

In patients with ventral hernias collagen type I/III ratio in skin is 2.54 times lower than in patients without hernias. Significant correlation of collagen types in skin and aponeurosis (r= +0.92) allows to predict the risk of postoperative ventral hernias on basis of skin fragment.

1 Кафедра хирургических болезней № 1, 2 кафедра хирургических болезней ФПО, 3 кафедра патологической анатомии, 4 кафедра гистологии, эмбриологии, цитологии Курского государственного медицинского университета, Курск; 5 кафедра гистологии, цитологии и эмбриологии Первого Московского государственного медицинского университета имени И.М. Сеченова, Москва;6 Городская клиническая больница им. С.П. Боткина, Москва В настоящее время лечение подавляющего числа больных с грыжами живота предусматривает только хирургическое лечение -эндопротезирование. Разработка и внедрение новых материалов для пластики непременно положительно сказывается на лечении больных с грыжами передней брюшной стенки, но не решает вопроса дисплазии соединительнотканных структур. Работа выполнено на 120 мышах (2 группы, по 60 особей). Оценка состояния соединительной ткани в парапротезной области производилась путем подсчета коллагеновых волокон I и III типов по результатам поляризационной микроскопии. Установлено коллагеностимулирующее действие препарата «Солкосерил». В сочетании с полурассасывающимся эндопротезом, «Солкосерил» достоверно ускоряет созревание парапротезных соединительнотканных структур и способствует увеличению их плотности.Ключевые слова: «Солкосерил», вентральная грыжа, коллаген, эндопротезирование, «Parietene ProGrip».

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