Annually more than 15 million children are born prematurely in the world. The clinical case illustrates the importance of an integrated approach for follow-up observation of children from 0 to 36 months old, born with very low and extremely low body weight. We studied the effectiveness of the Rehabilitation Center for children born with very low and extremely low body weight on the basis of a large multidisciplinary Bashlyaeva children’s hospital in Moscow 2012–2018. This center is necessary for a comprehensive assessment of the health status of children born with very low and extremely low body weight, as well as for the dynamic and timely diagnostics and the application of optimal treatment of revealed pathological changes. The development of differentiated programs for medical examination and rehabilitation of this group of children should include an optimal protocol of dynamic monitoring. It will reduce both the rate of incidence and disability, and improve the quality of life and social adaptation of children.