As a source of supply of a balanced complex of salts in pharmaceutical practice, sea water (MW), sea salt (MS), obtained by the method of ordinary evaporation, or salt solutions made from standardized raw materials are used. Deep seawater (SW), typically pumped from depths greater than 200 m, contains a wealth of trace elements, including magnesium, calcium, potassium, chromium, selenium, zinc, and vanadium. Due to this, SW has the potential of a source and raw material for the creation of medicinal products for human health. The purpose of the work was to research the assortment of preparations based on salts of natural origin and analyze the segment of such products on the pharmaceutical market of Ukraine as of June 2022. The research was conducted on the basis of data from the State Register of Medicinal Products of Ukraine, the Morion information search program, and the classification system of the ATS electronic resource Compendium.online. Methods of structural, statistical and graphic analysis were applied in the work, and their generalization and systematization was carried out. It was established that on the pharmaceutical market of Ukraine, the segment of medicines, medical products and cosmetics, the source of active substances of which is SW and/or SS, is represented by 150 trade names. It was determined that by type of registration, the most common are medical products (51%) and cosmetics (42%), only 7% of registered drugs are registered. Manufacturers use sea water obtained from the deep water basins of the Adriatic, Aegean, Mediterranean Seas, Atlantic Ocean, Kankal Bay, sea water of Gullmarsfjorden. Domestically produced drugs of the investigated market segment occupy a share of 57%. Among the importing countries, the leaders are Croatia (9%) and Poland (5%). The analysis of the nomenclature established that the most common medicinal form of the drugs are nasal sprays (78%). The obtained data show that as the active substance of saline solutions, manufacturers declare SS (56% of the nomenclature) and SW (53%), however, not all products contain information about the source of origin of SS/SW. It was determined that there are no products on the pharmaceutical market of Ukraine based on the SW and SS of the Black and Azov seas, which is the basis for research and the creation of new drugs of domestic production.