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The reactions of hydroxymethylcubanes with nitric acid result in the respective nitroxy methylcubanes.The search for the drugs to treat cardiovascular and oncological diseases is currently highly topical. The prepa ration of new polyfunctional compounds, study of their structures and properties will allow expansion of the spec trum of exogenous NO donors as potential drugs.Nitrates (or nitroesters) are a well known class of or ganic substances the pharmacological activity of which is determined by their metabolism with NO liberation (see Ref. 2). They include such compounds as Nitroglycerin, Nitrosorbide, Erinite, and others, which are commonly * For Part 9, see Ref. 1. † Deceased. Scheme 1used to treat ischemic cardiovascular diseases, for ex ample, stenocardia. It is known that cubane derivatives also show rather high anti ischemic activity. 3,4With the aim of search for new anti ischemic drugs, we performed the synthesis of nitroesters of the cubane series.Previously, 5,6 it has been shown that the reduction of dimethyl cubane 1,4 dicarboxylate (1a) and methyl 4 bromocubane 1 carboxylate (2) afforded 1,4 bis (hydroxymethyl)cubane (3) and 4 bromo 1 hydroxy methylcubane (4). In the present work, 1,4 bis(nitroxy methyl)cubane (5) and 4 bromo 1 nitroxymethylcubane

A hydrogel based on β‐cyclodextrin partial nitrate and oligo(ethylene glycols) of various molecular mass were synthesized by urethane formation reaction with hexamethylene diisocyanate. The influence of molecular mass of poly(ethylene glycol) and partial cyclodextrin content on mechanical and physico‐chemical properties of polyurethane hydrogel and its ability to swell in water was investigated. Additionally, cytotoxicity of partial cyclodextrin nitrates was studied.

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