Relevance. A study of the seasonal (phenological) phenomena and natural connections between them on the background of the relevant environmental conditions is of great scientific and practical interest. Knowledge of the dynamics of the seasonal development of woody plants helps in the selection of species and their assessment from an aesthetic and sanitary points of view, as well as in the development and implementation of measures to increase the sustainability of urban green spaces. Materials and methods. The purpose of these studies is to create a database of the dynamics of seasonal development of North American woody plants based on the results of many years of phenological monitoring (2003-2017). The 20 species and forms of North American woody introducers e of the VNIISPK arboretum genetic collection were the objects. Results. It was revealed that the growing season of woody North American plants corresponds to the climatic conditions of the forest-steppe zone of central Russia. The species with the earliest beginning of the growing season (the third decade of March) were distinguished. There were Mahonia pinnata, M. aquifolia, Betula lenta and B. lutea. On the basis of phenological calendars, phenological spectrums have been constructed. These consist of three lines (the development of leaves, shoots, flowers and fruits) with the corresponding color symbols. It has been revealed that phenospectrums vary depending on the conditions of the year. As a result, the database of 20 species and forms of North American woody plants was formed in the form of phenological spectrums against the background of registration of weather conditions in the forest-steppe zone of Russia. The database includes three options for the possible dynamics of the seasonal development of introduced North American plants. The created database allows observing, comparing, evaluating and forecasting changes in the seasonal rhythm of the studied species of introduced North American plants.

В связи с реализацией мероприятий национальных проектов «Наука», «Экология» остро стоят вопросы обеспечения посадочным материалом адаптированных древесных видов лесовосстановительных работ на деградированных территориях засушливых территорий. Цель исследований – разработка перспективных технологий размножения хвойных таксонов для лесомелиорации и озеленения с учетом их репродуктивных особенностей в засушливых условиях. Объекты исследований: лжетсуга Мензиеза (Pseudotsuga menziesii (Mirb.) Franco.), можжевельник виргинский (Juniperus virginiana L.), м. казацкий (sabinaL.), туя западная (Thuja occidentalis L.), плосковеточник восточный (Platycladus orientalis (L.) Franco), ель колючая ф. сизая (Picea pungens Engelm f. glauca Beissn.) коллекций, питомников, маточников Нижневолжской станции по селекции древесных пород – филиала ФНЦ агроэкологии РАН (кадастр. № 34:36:000014:178). Научные исследования направлены на решение теоретических и методических вопросов получения посадочного материала из адаптивного поколения древесных растений на основе изучения их репродуктивной способности. Выявлено качественные и количественные параметры семеношения и влияние лимитирующих факторов среды на развитие семян. Установлены особенности семенного размножения представителей древесных растений (хвойные таксоны) и разработаны технологические аспекты вегетативного размножения в условиях питомника Нижневолжской станции по селекции древесных пород (Волгоградская обл., Камышин) и комплекс мероприятий, обеспечивающих выращивание стандартного посадочного материала за один вегетационный период. Этот важный технологический прием в 2,8 раза увеличивает выход сеянцев с единицы площади, 87 % сеянцев достигают стандартных размеров, в 6 раз увеличивается абсолютно сухая масса сеянца. Внедрение научных разработок проводилось на производственных питомниках Нижневолжской станции по селекции древесных пород. В 2019 году было реализовано сеянцев и саженцев на сумму 6771024,12 рублей. Даны прогнозные предложения по развитию объекта – обновление производственной инфраструктуры станции, в т.ч. реконструкция питомника с целью формирования фонда посадочного материала для воспроизводства и использования коллекций биоресурсов деревьев и кустарников многоцелевого назначения. In connection with the implementation of the activities of the national projects "Science" and "Ecology", there are urgent issues of providing planting material for adapted wood types of reforestation in degraded areas of arid territories. The aim of the research is to develop promising technologies for breeding coniferous taxa for forest reclamation and landscaping, taking into account their reproductive characteristics in arid conditions. Research objects: Pseudotsuga menziesii (Mirb.) Franco.), Virginia juniper(Juniperus virginiana L.), M. kazatsky (J. sabina L.), Western thuja (Thuja occidentalis L.), Eastern flatwort (Platycladus orientalis (L.) Franco), prickly spruce (Picea pungens Engelm f. glauca Beissn.) collections, nurseries, brooders of the Nizhnevolzhskaya station for the selection of tree species – branch of the Federal Scientific Centre of Agroecology of the Russian Academy of Sciences (cadastre. № 34:36:000014:178). Scientific research is aimed at solving theoretical and methodological issues of obtaining planting material from the adaptive generation of woody plants based on the study of their reproductive ability. The qualitative and quantitative parameters of seed production and the influence of limiting environmental factors on the development of seeds were revealed. The features of seed reproduction of representatives of woody plants (coniferous taxa) and the technological aspects of vegetative propagation in a kennel Nizhnevolzhsky station on selection of tree species (Volgograd region, Kamyshin) and a set of activities to ensure the cultivation of standard planting material for one growing season. This important technological technique increases the yield of seedlings per unit area by 2.8 times, 87 % of seedlings reach standard sizes, and the absolutely dry weight of the seedling increases by 6 times. The introduction of scientific developments was carried out at the production nurseries of the Nizhnevolzhskaya station for the selection of tree species. In 2019, seedlings and saplings were sold for the amount of 677,1024. 12 rubles. Forecast proposals for the development of the facility are given – updating the production infrastructure of the station, including the reconstruction of the nursery in order to form a Fund of planting material for the reproduction and use of collections of bioresources of trees and shrubs for multi-purpose purposes.

BackgroundLittle is known about the association between ethnicity and response to TNF inhibitors (TNFi) in people with rheumatoid arthritis (RA).ObjectivesThis study examines the association between self-reported ethnicity and DAS28 response after 6 months of treatment in patients starting their first TNFi using data from the British Society for Rheumatology Biologics Register for RA.Methods14133 RA patients with self-reported ethnicity starting their first TNFi were included. Due to a very low proportion of non-white patients, ethnicity was divided into white or non-white for analysis. Outcomes included the change in disease activity using DAS28, the proportion of patients who achieved DAS28 remission and EULAR response at month 6. Adjusted regression models appropriate to outcome were used to compare between the two groups. Multiple imputation was used to account for missing data.ResultsOf 14133 patients starting TNFi with recorded ethnicity, only 607 (4.3%) recorded themselves as non-white (389 Asian, 134 Black, 57 Mixed ethnicity and 27 other) (Table 1). At start of TNFi, non-white patients were younger (non-white vs. white: mean 51 vs. 57 years; p<0.001), with shorter disease duration (median 8 vs. 10 years; p<0.001), higher proportion of females (86% vs. 76%; p<0.001) and fewer current cigarette smokers (9% vs. 20%; p<0.001). Non-white patients had lesser improvement in DAS28 at month 6 (adjusted regression coefficient (95% confidence interval (95%CI)): 0.3 (0.04-0.5)). However, using the white patients as a reference, non-white patients were not associated with the achievement of DAS28 remission (adjusted odds ratio (95%CI): 0.7 (0.5-1.1)) or EULAR response (aOR (95%CI): 0.8 (0.7-1.0)) at month 6.WhiteNon-whitepN13515607Age57.0±12.051.4±12.3<0.001Female (%)10262 (75.9%)520 (85.7%)<0.001Ethnicity (%)White13515 (100%)-Black-134 (22.1%)Asian-389 (64.1%)Mixed ethnicity-57 (9.4%)Other-27 (4.4%)Disease duration (years)10 (4-18)8 (4-15)<0.001RF positive (%)8341 (61.7%)390 (67.5%)0.08DAS286.4±1.16.4±1.10.4Tender joints15 (10-21)15 (9-21)0.6Swollen joints10 (6-14)9 (6-13)<0.001VAS75 (61-86)75 (61-88)0.9ESR35 (19-58)41 (25-65)<0.001CRP24 (10-53)19 (8-41)0.005HAQ1.9±0.61.9±0.70.4Biologic treatment (%)Adalimumab4107 (30.4%)165 (27.2%)0.1Certolizumab875 (6.5%)50 (8.2%)Etanercept5322 (39.4%)238 (39.2%)Infliximab3211 (23.8%)154 (25.4%)Concomitant csDMARDs (%)7595 (56.2%)340 (56%)0.9Methotrexate (%)5512 (40.8%)243 (40.0%)0.7Concomitant glucocorticoids (%)5017 (37.1%)199 (32.8%)0.03Current cigarette smoking (%)2698 (20.0%)57 (9.4%)<0.001Response to first-line TNFi at month 6DAS28 at month 64.7±1.85.0±1.80.02ΔDAS28*1 [reference]0.3 [0.04-0.5]0.02DAS28 remission (%)13%11%0.1Odds of DAS remission*1 [reference]0.7 [0.5-1.1]0.1Good EULAR response (%)18.2%16.5%Moderate EULAR response (%)33.7%33.2%Odds of achieving higher EULAR response*1 [reference]0.8 [0.7-1.0]Data is expressed as mean±SD, median (interquartile range), number (percentage), adjusted regression coefficient [95% confidence interval] or adjusted odds ratio [95% confidence interval].*Adjusted for baseline age, gender, disease duration, concomitant csDMARDs, concomitant steroid, rheumatoid factor status, cigarette smoking status, DAS28 and HAQConclusionRecruitment to the BSRBR-RA of non-white patients was exceptionally low compared to expected population distribution – the reasons for this are not immediately evident. Among those recruited, there were no significant differences observed in initial treatment response although non-white patients were younger, more likely to be female, had shorter disease duration and less likely to be smokers. Further evaluation into both ways to increase representativeness in our national RA treatment register and influence of ethnic differences on longer term outcomes with biologic therapies is warranted.ReferenceNIL.Acknowledgements:NIL.Disclosure of InterestsMan Fung Tsoi: None declared, Rajinder Singh Andev Speakers bureau: Speaker fees from Novartis, Lianne Kearsley-Fleet: None declared, Kath Watson: None declared, Shirish Dubey Speakers bureau: Speaker fees from Janssen, Consultant of: Honoraria from Boehringer Ingelheim, Kanta Kumar: None declared, Arumugam Moorthy Speakers bureau: Novartis and Galapagos, Consultant of: Honoraria from Lilly and UCB, Monica Gupta: None declared, Adewale Adebajo: None declared, Kimme Hyrich Consultant of: Honoraria from Abbvie, Grant/research support from: Pfizer and BMS, and is supported by the NIHR Manchester Biomedical Research Centre.