A large number of diseases with different etiology and pathogenesis, at different stages of their development, can have a similar clinical manifestation - a pain in the lower back and proceed masked, namely, in the form of different variants of dorsopathies. Not all of these diseases are associated with degenerative-dystrophic processes in the vertebral motor segment and myofascial disorders. A number of cancer diseases may occur with lesions of the spine both primary and secondary. In turn, this causes a clinical picture that is similar to the symptoms of dorsopathy, however, it requires a completely different treatment. A latent cancer course, the absence of proper medical examination of the people, incomplete examination, at first glance "easy" patients can lead to serious diagnostic errors, and as a consequence, incorrect treatment, with all the ensuing irreparable to the patient´s health consequences. Such patients at any time may be on the appointments to specialist for vertebra-neurological patients (manual therapists, reflex therapists, osteopaths and others). Both beginners and experienced doctors should always remember this. The authors of this article draw attention to this. This article presents clinical picture and pain syndrome of the most common tumors and distinguishing features of it at the dorsopathies. This information, as well as clinical cases considered in this paper will allow the specialist to sus-pect possible oncological implications of pain in the patient and recommending further examination to avoid serious medical errors.