Subject: the incidence of periodontal disease among the adult population of the Russian Federation reaches 95-100%.It is known that the microbiota of dentofacial pockets is characterized by instability, uncontrolled pathogenic factors, the presence of difficult-to-culture species. In recent years, the use of balneotherapy, mineral therapy, phyto-aromatherapy and others that do not cause side effects and addiction in the complex treatment of chronic diseases is considered a successful trend in modern periodontics. Purpose: the aim of this work was to study changes in the nature of the microflora of the periodontal apparatus in chronic gingivitis (CG), chronic generalized periodontitis (present study included) on the background of the use of non-pharmacological treatment technologies, including integrated ozonized balneotherapy. Methodology: the positive effect was obtained from the influence of ozonated compositions series named "Biol" and "Phyto-Biol" on the periodontal tissue microflora among patients with catarrhal gingivitis (25 people) and generalized periodontitis (23 people). Results of the study. Against the background of the course of complex balneo-hydrotherapy, the disappearance of pathogenic species occurred in a shorter time (3-5 days in patients with CG, on the 7th day with CGP) compared to the control group (7 and 10 days, respectively). It was stated that the use of ozonized mineral drugs in combination with hydrotherapy with ozonized Saki mineral water "BENTATM" has a local therapeutic effect on chronic gingivitis and chronic generalized periodontitis, promotes more rapid recovery of gingival sulcus and periodontal bag’s normobiosis, rather than drugs without ozone. Conclusions: the most prolonged effect was demonstrated by phytocompositions that contain ozone and "BENTATM" which are recommended to be applied in cases of clinical periodontics, surgical, orthopedic dentistry in invasive manipulation, treatment of periodontal tissues, prevention of complications and recurrences.