The probability of groundwater contamination is high enough because groundwater has different origins: a majority of them are formed by atmospheric precipitation filtration through soil layer or due to condensation of water vapors directly into the ground. Pesticides could be one of such hazardous groundwater pollutants. We developed two methods for the hazardous effect on human organism while consuming contaminated water prediction: risk acceptance assessment and integral groundwater contamination hazard index (IGCHI) evaluation in points according to special scale.

Relevance. Evaluation of occupational risk in the application of various groups and classes of pesticides is an actual problem, since it is known that chemical plant protection products can cause both acute poisoning and long-term effects of the action, including neurotoxic effects if the application rules are not followed. Objective of the work was a hygienic assessment of the working conditions and occupational risk of workers when using pesticides Ampligo 150 ZC, Banjo Forte, SC, Blockbuster, CE, Zero, CE, Cloti-200, SC, Mistral Top, SC, Mistral, WG, Paritet, SC, Remontal, WG, Stomp Aqua, SC, T-2, SC, Fronda, SC on potatoes to substantiate the regulations for their safe application. Materials and methods. The occupational risk assessment was carried out in accordance with the methodological recommendations proposed by the specialists of the L.I. Medvedia Scientific Center for Preventive Toxicology, Food and Chemical Safety. Statistical processing of the results was performed using the IBM SPSS Statistics Base v.22 and MS Excel software licensed statistical package (version 12.0.6425.1000, 2007). Results. It has been established that in real conditions of potatoes treatment with Ampligo 150 ZC, Banjo Forte, SC, Blockbuster, CE, Zero, CE, Cloti-200, SC, Mistral Top, SC, Mistral, WG, Paritet, SC, Remontal, WG, Stomp Aqua, SC, T-2, SC, Fronda, SC, while observing the recommended agrotechnical and hygienic regulations for safe application, there is no excess of hygienic standards in the working area air and it is proved that the Hygienic regulations of studied formulations safe application have been substantiated. Conclusion. A statistical analysis of the results showed that the magnitude of inhalation risk was significantly higher for tractor drivers than for refuellers (p<0.05). The value of the combined complex risk of the studied formulations application for refuellers was significantly lower than that for the tractor drivers.

Methods for determining the toxicological parameters of pesticides are long-term, labor-intensive and require significant financial and resource costs, which is why laboratories do not always cope with the increasing flow of chemical plant protection products. In solving this problem, the important role is played by methods of mathematical modeling and prediction of xenobiotics toxicity. The aim of the research is the scientific substantiation of the possibility of creating and using of calculation models for predicting the toxicity of various classes of fungicides. Materials and methods. Toxicometry indices and physico-chemical parameters of widely used in the world agriculture fungicides were used for analysis. Statistical processing of the results was carried out using IBM SPSS StatisticsBase v.22 and MS Exсel statistical program packages. Results. Significant correlation dependences between the toxic properties of fungicides of the class of pyrazole-carboxamides, carboxamides, triazoles, imidazoles, carbamates, dithiocarbamates, methoxyacrylates and their physico-chemical properties were found. Discussion. In most of cases, the calculated values correlated with experimentally established. For all valid pairs of resultant and factorial variables, a reliable correlation relationship was established. Conclusion. It was proved that the proposed calculation models for forecasting the hazard of studied fungicides are adequate and significant. The developed algorithm makes it possible to substantially simplify the conduction of toxicological experiments provided that there are data on the physical and chemical properties of the studied compounds and to accelerate the procedure for registration of new fungicides of the studied classes

Estimation of modern range of fungicides and scope of their application in agriculture of Ukraine as component of state social and hygienic monitoring. Vavrinevych O.P., Omelchuk S.T., Bardov V.G. The analysis of the range of pesticides, including fungicides, authorized for use in Ukraine and the scope of their application during 1999-2012 years was carried out. Statistical research methods were used in the analysis, evaluation of the results was carried out in terms of the rate of growth and increase. It was determined that in the range structure of pesticides, authorized for use in Ukraine the largest share accounted for herbicides.

Background. The diseases of thyroid gland have been attracting considerable attention in recent decades. This is partly due to the fact that thyroid gland reacts actively to geochemical state and pollution of the environment with industrial and agricultural waste products with the subsequent incidence of certain pathological processes. The objective of the research was to analyze the morbidity of adult population of Ukraine for thyroid gland diseases in the period from 2000 to 2013.Methods. The methods of empirical and theoretical research of scientific information: analysis, synthesis, induction, deduction and systematization, as well as epidemiological and statistical methods were used. Using the Microsoft Office Excel (2007) and IBM SPSS StatisticsBase v.22 program the correlation and regression analyzes were conducted.Results. From 2000 to 2013, high levels of adult population endocrinopathies, thyroid in general and diffuse goiter of varying degrees, general and primary morbidity were registered in the western and northern regions of Ukraine, low – in the central, eastern and southern regions. Statistically significant (p<0.001) positive correlation between the level of prevalence and the level of incidence of endocrine pathology, diseases of thyroid gland as a whole, as well as individual nosology was detected. Conclusions. Regional peculiarities of the levels and dynamics of changes in the incidence rates of thyroid morbidity among adult population of Ukraine can be related to the urgent environmental factors for each region. This factor requires further study to develop effective methods of prophylaxis and defense.