Microbiological monitoring of the uropathogens is an effective "tool" for urinary tract infectious and inflammatory diseases treatment quality improvement. The aim of the article is to determine the range of the urinary tract infectious-inflammatory diseases etiological spectrum groups of pathogens in the child population in Chernivtsi region. Materials and methods. The etiologic spectrum of uropathogens identified in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology Department of the "Municipal Children's Clinical Hospital", Chernivtsi (2014-2015) was analyzed in order to dynamically control the possible changes of the "urinary tract infections" (UTI) regional etiological structure and antibiotic resistance of pathogens; identification of age and gender differences of urine microbial diversity in the child population in Chernivtsi region (2014-2015) compared with the monitoring data for the 2009-2013 period. Results. A significant difference has been found in the etiological structure of the urine microbial diversity in children with infectious and inflammatory diseases of the urinary tract (Gram-positive cocci-p < 0.05; Enterobacteria-p < 0.01; resident microflorap < 0.01) in comparison with uropathogens extracted in children with urinary tract noninfectious diseases. Administrative and territorial differences have been registered in etiological structure of the urine microbial diversity in children living in the urban areas (p < 0.01) from their peers living in the rural areas. Conclusions. The regional monitoring data showed changes of the urine resident microflora (p < 0.01) without significant changes of etiological spectrum of the UTI pathogens in examined children (0-18 years old) with urinary tract infectious and inflammatory diseases during 2009-2015 in Chernivtsi region. At the same time it as a matter of concern a significant increase in the proportion of "negative results" (no growth) in the urine bacteriological analysis (p < 0.01), which might indirectly indicate the "uncontrolled" use of antibiotics among children in the region.

Objective: To evaluate the potential effect of poly-vitamins and probiotics use among preschool children permanently living within iodine deficiency territory on caries prevention. Material and Methods: 80 children aged 2-3 years old were randomly distributed among the study group (21 male and 19 females) and control group (20 males and 20 females). Oral fluid samples were formed from each study subject during primary examination and after 1 year of monitoring, which further were analyzed by parameters associated with mineralization potential of oral fluid. Both groups were provided with oral hygiene educational training, while the study group was also prescribed with poly-vitamin-mineral drug complex and probiotics. Results: After 1 year of monitoring, no significant changes considering caries prevalence (p>0.05) or intensity (p>0.05) values were registered among study and control groups. Difference of free calcium level, phosphate ion level and alkaline phosphatase activity was statistically approved (p<0.05) while comparing between study and control group after 12 months of monitoring. Conclusion: Caries preventive approach consisted of oral hygiene educational training and course of properly prescribed poly-vitamins and probiotics intake demonstrates positive results related to the changes within mineralization potential of oral fluid among preschool children with long-term residence over geographically associated iodine-deficient territory.

In the scope of current medical practice the "viewpoint" regarding the growth of antibiotic resistance of microorganisms is a threat to national security. A reasonable use of antibiotics on the basis of uropathogen regional bacterial sensitivity gives the opportunity to "restrain" the growth of antibiotic resistance of microorganisms and increase the effectiveness of the UTI treatment.The aim of the article is to determine the range and dynamics of the antibiotic resistance of major groups of infectious-inflammatory diseases causative agents of the urinary tract in the child population of the Chernivtsi region. Materials and methods.The analysis of etiologic spectrum and antibiotic resistance of uropathogens was conducted and observed in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology department of the "Municipal Children 's Clinical Hospital", Chernivtsi (2014 with the purpose of the dynamic control of possible changes in the regional antibiotic resistance of pathogens of causative pathogens of the "urinary tract infections" (UTI); identify the age and gender differences of the child population of the Chernivtsi region (2014)(2015) compared to the monitoring data for the period of 2009-2013.Results. When UTI among of the child population of the Chernivtsi region leading etiologic organisms include strains of the family Enterobacteriaceae and uropathogen of the genus Proteus. A "wave-like" curve of the dynamics of antibiotic resistance of Enterobacteriaceae uropathogens with a decreasing tendency to the "drugs of choice" was observed among the child population of the region (2009)(2010)(2011)(2012)(2013)(2014)(2015): penicillin (P < 0.01), cephalosporin II-III generation (P < 0.01) and medicine of the fluoroquinolone series (P < 0.01). A "wave-like" curve of the dynamics of antibiotic resistance of Proteus uropathogens with a decreasing tendency to the "drugs of choice" was observed among the child population of the region (2009)(2010)(2011)(2012)(2013)(2014)(2015): semi-synthetic penicillin (P < 0.1), and medicine of the tetracycline series (P < 0.01). Conclusions.Regional microbiological monitoring of the uropathogens is an effective "tool" in higher quality treatment of infectious and inflammatory diseases of the urinary tract of the child population.Регіональний моніторинг антибіотикорезистентності збудників інфекцій сечової системи серед дитячого населення Чернівецької області Сучасний «погляд» у світовій медичній практиці щодо зростання антибіотикорезистентності мікроорганізмів -загроза національної безпеки. Раціональне використання антибіотиків, на підставі даних про регіональну бактеріальну чутливість уропатогенів, дає можливість «стримувати» зростання антибіотикорезистентності мікроорганізмів і підвищити ефективність лікування інфекційно-запальних захворювань сечової системи.Мета роботи -встановити динаміку антибіотикорезистентності основних груп збудників інфекційно-запальних захворювань сечової системи в дитячого населення Чернівецької області.Мате...

Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009–2016 with intermediate results from 2020–2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0–17 years old) treated at the health care institutions in the Chernivtsi region (2009–2016). The clinical-laboratory examination of 177 children (0–17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020–2021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01) and imipenem – χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem – χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020–2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.

STATE OF CONNECTIVE TISSUE ELEMENTS OF THE DENTAL-MAXILLARY SYSTEM IN CHILDREN WITH DIFFUSE NONTOXIC GOITER