The results obtained suggest that common upper airway pathogens do not play a major role in the pathogenesis of chronic rhinosinusitis. The microbiome of inflamed sinonasal mucosa is extremely diverse and involves exotic species of bacteria that, to date, have not been considered as potential inhabitants of the paranasal sinuses.

Cyclamen europaeum improves the effect of oral antibiotics on exacerbations and recurrences of chronic rhinosinusitis: a real-life observational study (CHRONOS) L'estratto di Cyclamen europaeum per via intranasale implementa l'effetto degli antibiotici orali nel trattamento delle riacutizzazioni delle rinosinusiti croniche: studio osservazionale in vivo (CHRONOS)

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