The research results of the effect of essential oils on the human short-term image and numerical memory have been described. The study involved 79 secondary school students (34 boys and 45 girls) aged 13 to 17 years, residents of the Ukrainian metropolis. Participants were divided into three groups: the control group, ''Lavender" group, in which the lavender essential oil was sprayed, and ''Rosemary" group, in which the rosemary essential oil was sprayed. The statistically significant differences in productivity of the short-term memory of the participants of different groups have been found. Therefore, the essential oils of rosemary and lavender have significantly increased the image memory compared to the control. Inhalation of the rosemary essential oil increased the memorization of numbers, and inhalation of the lavender essential oil weakened this process.

acid anilides has been carried out. The antitubercular activity and the effect on the urinary function of the kidney have been studied for the compounds prepared. A structure-biological activity relationship is discussed.In recent times the attention of synthetic chemists has been drawn to a search for biologically active substances in order to create from them novel medicinal compounds and it has been ever more attracted to 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides [2][3][4][5][6][7][8]. This is explained not only by the broad spectrum of pharmaceutical activity of the studied 4-hydroxyquinol-2-ones and their natural occurrence but also by the ready chemical modification of their basic structure. Directed changes can be introduced into any part of the basic molecule by quite simple methods guaranteeing the best access to an almost unlimited range of analogs which, in turn, significantly increases the likelihood of discovering promising structural leads in subsequent study.Condensation of primary aromatic amines with triethyl methanetricarboxylate in conventional conditions gives primarily the methanetricarboxylic acid trianilides. During microwave irradiation the reaction given occurs somewhat differently and indeed yields 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides [7]. To some extent, the low yields are compensated by the synthesis of the target compounds in a single stage. This method is certainly of interest although the promising application of it is small since both the quinolone ring and the anilide fragment are formed from the same aniline.

Hypertensive disease is not by chance considered to be one of the main problems in current medicine. This is not simply a disease, but it intrinsically decreases the quality of human life. Unfortunately, it is also a factor triggering a cascade of many pathological changes in various organs and tissues and leads to a whole series of other illnesses and pathological conditions, which contribute to widespread complications and a sharp increase in mortality. In the last decade, diuretics have secured a place in the treatment of arterial hypertension and chronic heart failure. Although being not strictly antihypertensive medicines, they lead to the elimination of a large amount of liquid from the organism thus lowering arterial pressure to a physiological norm [2, 3]. Indapamide is a particularly widely used medicine amongst this pharmacological group [4][5][6][7][8][9]. Our interest in this medicine is due not only to its biological properties. Its known structure [10] is a 2-methylindoline derivative. Quite recently, compounds with a high diuretic activity and clear antihypertensive and antiedematous properties have been found amongst 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides [11] structurally based on an unsubstituted indoline. From this there arose the idea of including methylated analogs of the above mentioned pyrroloquinolines into our search for novel diuretic compounds.

The research results of the effect of essential oil of rosemary on the human short-term image and numerical memory have been described. The study involved 53 secondary school students (24 boys and 29 girls) aged 13-15 years, residents of the Ukrainian metropolis. Participants were divided into the control group and ''Rosemary" group, in which the rosemary essential oil was sprayed. The statistically significant differences in productivity of the short-term memory of the participants of these two groups have been found, while sex differences in uniform groups were absent. Therefore, the essential oil of rosemary has significantly increased the image memory compared to the control. Inhalation of the rosemary essential oil increased the memorization of numbers as well.

A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents. The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance of a "structure -diuretic activity" relationship is discussed.In recent years along with the well known efficient use of diuretics in the treatment of kidney deficiency [2], glaucoma [3], epilepsy [4], and insipid diabetes [5, 6] the attention of pharmacologists and doctors has been increasingly paid to currently uncommon areas of use of the extrarenal effects of diuretic medicines in the treatment of bronchial obstruction syndrome, mucoviscidose [7], oncological [8,9], and a series of other illnesses. There is particular interest in the medicinal uses of diuretics which show both their diuretic properties together with anti-inflammatory [10,11], antioxidant [12, 13], antimicrobial [14, 15], cholagogue [16], hepatoprotective [17], hypolipidemic [18], and other useful activity. Even a cursory glance at the literature shows a marked and steadily increasing tendency to broaden the catalog of indications for diuretic agents in clinical practice. At the same time, over the last 30 years not a single class of novel diuretic has appeared in the world pharmaceutical market although the need for such preparations is obvious.It is interesting that quinoline type compounds have not been considered up to recent times as possible diuretic agents because such a type of pharmacological activity is considered atypical. None the less, in the process of carrying out systematic investigations, potential diuretics have been discovered by us amongst 4-hydroxyquinol-2-ones. It was possible to discover an interesting relationship, particularly fully and clearly identified in the case of amide derivatives of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acids. As a result it was convincingly shown that the level of the diuretic effect of the quinolone compounds depends significantly on the structure of the amide fragment and increases in the sequence: alkylamides < cycloalkylamides < 3-arylpropylamides < 2-arylethylamides < benzylamides << anilides [19,20].