Introduction. A Hormon-like agent such as phenol is able both to integrate into the work of hypothalamus-pituitary-ovary system and trigger a cascade of responses that leads to the development of the immune, hormonal and endocrine systems disorder. Material and methods. The study included 181 woman who permanently live in the area with contamination with phenol in air above standard level. All women are comparable in age, material status and ethnicity. Immunological and hormonal indices were determined by enzyme immunoassay, genetic markers were detected by polymerase chain reaction. Statistical data processing was carried out with the soffware Statistica 10.0, using parametric and non-parametric methods. Results. Between the study groups there were obtained significant differences in following markers: thyroid-stimulating hormone, serotonin, interleukin 6, interleukin 10, estradiol. The dependence of appearance of unfavorable reproductive effects on the presence of polymorphic allele’s was determined: A allele of a gene SULT1A1, G allele of a gene PER2, C allele of a gene SIRT1. Correlation models are defined: thyroid-stimulating hormone and phenol, serotonin and phenol, thyroid-stimulating hormone and cresol, serotonin and cresol, estradiol and cresol. Conclusion. All found markers (increased concentration of phenol in biological media, gene polymorphism, altered protein and receptor expression) create special conditions for the course of the miscarriage pathology.

Introduction. The object of the study is the results obtained during the implementation of the Federal Project (FP) “Clean Air” in 2020 in the supervised participating cities and the assessment of the possibility of implementing the tasks set for Rospotrebnadzor for effective health risk management, reducing morbidity and mortality of the population. The purpose of the study is to assess the risk to public health according to the summary calculations of atmospheric air pollution in the cities of Cherepovets, Lipetsk, Omsk, Novokuznetsk during the implementation of the FP “Clean Air” (baseline, 2017). Materials and methods. The primary approach to implementing the FP “Clean Air” in 2020 is to use the initial data (summary calculations of atmospheric air pollution) and obtain on their basis the levels of exposure and risks to public health. A software product of the “Ecolog-Gorod” series was used to calculate single and average annual concentrations. The health risk assessment procedure was carried out under the requirements of the manual R 2.1.10.1920-04. Results. Studies were conducted to assess the risk to public health based on the data of summary calculations of atmospheric air pollution in the cities participating in the FP “Clean Air” (Cherepovets, Lipetsk, Omsk, Novokuznetsk) in 2017 before the start of the measures provided for by the Comprehensive Plans to reduce emissions of pollutants into the atmospheric air. The assessment of the public health risk from atmospheric air pollution made it possible to establish: priority compounds contained in industrial emissions, the primary industrial sources and their share contribution, as well as the contribution of motor transport and independent heat supply sources emissions to the formation of pollution levels in cities; the population exposed to unacceptable risk levels were determined; substances that should be taken into account when quoting emissions were identified. The variants of improving the quality of preparation of the initial data of summary calculations for health risk assessment are recommended. Conclusion. There are suggested approaches to improving the quality of preparation of initial data of consolidated calculations for health risk assessment.

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