No abstract

Aim: To evaluate activity of oxidative stress (OS) as marker of vascular aging in different age groups of patients with combined course of arterial hypertension (HT) and type 2 diabetes mellitus (T2DM). Methods: 126 patients (average age 57.8 ± 6.2 years) with stage II HT and compensated T2DM were divided into 2 subgroups: 2a (n = 59)-aged 45-60 years; 2b (n = 97)-aged 61-75 years; 30 patients with isolated stage II HT (comparison group), 20 practically healthy individuals (control group). The activity of antioxidative [glutathione peroxidase, sulfhydryl groups (SH-groups)] and oxidative [malonic dialdehyde (MDA)], 8-hydroxy-2-deoxyguanosine (8-OH-dG) systems in blood serum, were studied. Results: A significant increase in MDA levels (P < 0.05) and SH-groups (P < 0.05) compared with healthy volunteers was observed. Patients in 2b group had lower MDA values than in 2a (6.25 ± 0.33 μmol/L, 7.07 ± 0.44 μmol/L, respectively, P > 0.05). In the 2b group, in comparison with 2a patients, a decrease in thiol status was observed (P > 0.05). The level of 8-OH-dG was increased in patients with HT and T2DM, but there was also an age-associated increase in the average 8-OH-dG in the 2b group. Conclusion: The age-associated changes in the OS in comorbid course of HT and T2DM did not have significant differences. Nevertheless, the presence of correlations between various indexes that are included in the concept of "vascular aging" and indicators of oxidant-antioxidant systems in different age groups allows us to make an assumption about the significant influence of the oxidative status on the status of vascular age, especially in the older age group persons.

No abstract

How to cite this article: Bilovol O. Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity. Vessel Plus 2017;1:22-8. Aim:These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β, IL-4, and IL-6 were measured. Lipid and carbohydrate metabolism rates were assessed. Results: Peak homeostatic model assessment for insulin resistance (HOMA-IR) index values, as well as circulating insulin and CRP levels, were observed in group 2. Reduced adiponectin levels negatively correlated with HOMA-IR indices (r = -0.52, P < 0.05), triglycerides (r = -0.52, P < 0.05), glucose levels (r = -0.44, P < 0.05), body mass indices (r = -0.44, P < 0.05), and HbA1c levels (r = -0.57, P < 0.01). Group 2 patients demonstrated low omentin levels and high resistin and TNF-α levels. Negative correlations between IL-6 and both omentin and adiponectin (r = -0.46, P < 0.01; r = -0.42, P < 0.01, respectively) were observed. Conclusion: A novel pathogenic link was demonstrated between metabolic disorders, adipokines, and pro-inflammatory IL-6 levels as negative regulators of comorbid AH and T2DM. Key words:Hypertension, type 2 diabetes mellitus, adipokines, interleukins ABSTRACTArticle history:

No abstract