The synthesis of new analogs of natural biologically active substances is a promising direction for the development of effective antifungal agents. Thiosulfonic acid esters (thiosulfonates) are the structural analogs of biocidal compounds from garlic, onion, cabbage, cauliflower, etc. More than 1000 thiosulfonates of various structures of the general formula RSO 2 SR' were synthesized at the Lviv Polytechnic National University, where their physicochemical properties were characterized. A high antifungal activity of the obtained substances was established in relation to the representatives of fungi of different genera. The thiosulfonates are perspective as basis for the development of effective antifungal means for the modern pharmaceutical, food industry, for the protection of various materials and agricultural products. To increase their effectiveness, antimicrobial compositions based on thiosulfonates and surfactants of microbial origin (biosurfactants) in the form of stable suspensions were developed and studied. It has been established that the use of biosurfactants in the compositions allows the enhancement of the antifungal activity of thiosulfonates and reduction of their active concentration. The possible mechanisms of the joint action of thiosulfonates and biosurfactants on fungal pathogens are proposed.

The antimicrobial composition based on the substance of thiosulfonate structure (ETS) and surfactants of microbial origin (biosurfactants) in the form of stable suspensions and ointments were developed and investigated for their effectiveness. The application of biosurfactants in the preparation enhances the antifungal and antibacterial activity of ETS and reduces its active concentration. The economic calculations have shown that the developed antimicrobial composition has a low cost and is competitive compared with antifungal agents present in the pharmaceutical market.

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The influence of different agriculture systems and measures of basic tillage on nutrient regime, its relation to the number of microorganisms involved in transformation of organic matter in typical black soils was studied. Direction of the formation processes of some physiological indices in the field of wheat winter was investigated. It was found that the most favorable conditions of nutrition and soil microflora development, as well as indices of crop growth and development are created when using ecological system of agriculture.

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