Reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-hetarylamides with copper, zinc, and cadmium dichlorides led to the formation of bis[3-aryl-1-(N-hetaryl)carboxamido-1,3-propanedionato]copper, -zinc, and -cadmium, respectively. Compounds with high antimicrobial activity were found among these products. 3890091-150X/08/4207-0389

The reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-heterylamides with dichlorides of manganese, cobalt, and nickel forms the bis[3-aryl-1-(N-heteryl)carboxamido-1, 3-propanedionato] complexes of manganese, cobalt, and nickel, respectively. The hypoglycemic and anti-inflammatory activities of the synthesized compounds and the previously obtained complexes of copper, zinc, and cadmium were investigated. Several highly active substances with two pharmacological effects were found among these products.

Application of probiotics at antibiotic treatment is the effective therapeutic reception reducing negative consequences for a macroorganism microbiota in general. At such universal approach it is necessary to take the factors defining the beginning of reception of probiotics into account: to, in time or after the termination of a rate of antibacterial medicines. At purpose of simultaneous application it is advisable to consider impact of the recommended antibiotic on cellular pro-biotic medicines and to give preference less sensitive. At a comparative research by means of disco - a diffusive method of sensitivity mono - and multicomponent pro-biotic medicines to various antibiotics the essential differences allowing to range priority of their application with the appointed antibacterial medicines are revealed. Development of recommendations about combined use anti-and probiotics for optimization of courses of antibacterial therapy and increase in efficiency of complex therapy of various diseases has to be a consequence of such researches.

A multicomponent probiotic is an effective remedy for correction the disbioticheskikh of conditions of the person and is applied in complex therapy of various diseases. When developing simbiotik it is necessary to pay attention both compatibility of the used bacterial cultures, and to ensuring necessary level of standardization of these medicines. Application of the control methods allowing to define differentially quantity of viable cages of each strain in a medicine dose is the necessary instrument of standardization of simbiotik. Realization of such approach is shown on the example of the medicine "Bifilakt-BILS" containing lakto-and bifidobacteria which separate calculation is caused by use the mezhshtammovykh of distinctions of cultural properties, including activity of souring of milk, an antibiotikochuvstvitelnost, aerobic conditions. The developed control technique for this medicine is an alternative of expensive option on the basis of polymerase chain reaction.