L'étude des types de la mort cellulaire et les stades de l'apoptose des leucocytes chez les patients atteints de la tuberculose pulmonaire aux différents programmes de traitement antimycobactérien L'objectif. D'évaluer l'état des membranes cytoplasmiques des leucocytes et étudier leur viabilité, déterminer les variétés et les stades de la mort cellulaire des leucocytes chez des patients avec tuberculose pulmonaire traités par différents schémas de traitement antimycobactérien. Matériaux et méthodes. L'étude a été réalisée sur 30 patients atteints de tuberculose pulmonaire: 1er groupe-12 patients traités par un schéma thérapeutique standard avec des médicaments en ligne; 2-ème groupe-patients traités individuellement avec les médicaments de la gamme I et II. Le groupe témoin comprenait 12 donneurs en bonne santé. L'étude a été réalisée par la cytométrie en flux sur un cytomètre en

Background. Tuberculosis is still one of the urgent medical and social problems and poses a threat to human health around the world. Purpose of work: To study the features of rifampicin-resistant tuberculosis in male and female patients with alcohol dependence syndrome. Material and methods. The subjects were 219 patients with active rifampicin-resistant pulmonary tuberculosis and a diagnosis of alcohol dependence syndrome. During the study, two groups of patients were formed: group I – the main group (n=33) – included females with rifampicin-resistant pulmonary tuberculosis and alcohol dependence syndrome, group II – the comparison group (n=186) – was composed of males with rifampicin-resistant pulmonary tuberculosis and alcohol dependence syndrome. Results. Termination of bacterial excretion, confirmed by the bacteriological method, was obtained in 60.6% of the patients in the main group and in 57.2% of the patients in the comparison group (p>0.05). The analysis of radiological data (plain chest radiograph, linear tomogram) showed that closure of the decay cavities in the lungs was observed only in 6 (28.6%) and 50 (49.1%) cases (p<0.05), respectively. Conclusions. The modern social picture of rifampicin-resistant tuberculosis is represented by working-age individuals suffering from alcohol dependence syndrome, those who are not employed, women of reproductive age.

Цель исследования: определить протективные генотипы по изученным локусам у больных туберкулезом разных групп. Материалы и методы. В исследование включено 568 пациентов. Группу I составили 43 пациента с очаговым туберкулезом легких, группу II-279 пациен

Rifampicin-resistant tuberculosis (RR-TB) – multi-drug and extensively drug-resistant tuberculosis (MDR and XDR) – is a global problem. Purpose of the work. To study the features of RR-TB combined with alcohol dependence syndrome (ADS). Material and Methods. A total of 420 patients with active pulmonary TB were examined. All patients were divided into groups depending on the presence or absence of ADS. The patients with ADS were referred to the main groups (MG), those without ADS – to the comparison groups (CG). Results. When evaluating the outcome of the main course of treatment in patients with MDR-TB without ADS, the indicator of "successful treatment" was achieved in 88.6% of patients, and in those with MDR-TB combined with ADS – in 58.0% (<0.05). The indicator "successful treatment" was confirmed only in 26.8% of patients with MBT XDR. When XDR-TB was combined with ADS the indicator of "successful treatment" was obtained in 20.4% of patients, the outcome "death" was present in 52.3%, all cases due to TB. In the treatment of XDR-TB without ADS, "successful treatment" was achieved in 65.4% cases, the outcome "death" was in 11.5%. Conclusions. RR-TB in combination with alcohol dependence syndrome is a serious problem. It has been established that the absence of alcohol dependence syndrome in patients with MDR-TB allows for effective anti-TB treatment and good results.

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