No abstract

Известия Национальной академии наук Республики Казахстан 2 NAS RK is pleased to announce that News of NAS RK. Series of chemistry and technologies scientific journal has been accepted for indexing in the Emerging Sources Citation Index, a new edition of Web of Science. Content in this index is under consideration by Clarivate Analytics to be accepted in the Science Citation Index Expanded, the Social Sciences Citation Index, and the Arts & Humanities Citation Index. The quality and depth of content Web of Science offers to researchers, authors, publishers, and institutions sets it apart from other research databases. The inclusion of News of NAS RK. Series of chemistry and technologies in the Emerging Sources Citation Index demonstrates our dedication to providing the most relevant and influential content of chemical sciences to our community. Қазақстан Республикасы Ұлттық ғылым академиясы "ҚР ҰҒА Хабарлары. Химия жəне технология сериясы" ғылыми журналының Web of Science-тің жаңаланған нұсқасы Emerging Sources Citation Index-те индекстелуге қабылданғанын хабарлайды. Бұл индекстелу барысында Clarivate Analytics компаниясы журналды одан əрі the Science Citation Index Expanded, the Social Sciences Citation Index жəне the Arts & Humanities Citation Index-ке қабылдау мəселесін қарастыруда. Webof Science зерттеушілер, авторлар, баспашылар мен мекемелерге контент тереңдігі мен сапасын ұсынады. ҚР ҰҒА Хабарлары. Химия жəне технология сериясы Emerging Sources Citation Index-ке енуі біздің қоғамдастық үшін ең өзекті жəне беделді химиялық ғылымдар бойынша контентке адалдығымызды білдіреді. НАН РК сообщает, что научный журнал «Известия НАН РК. Серия химии и технологий» был принят для индексирования в Emerging Sources Citation Index, обновленной версии Web of Science. Содержание в этом индексировании находится в стадии рассмотрения компанией Clarivate Analytics для дальнейшего принятия журнала в the Science Citation Index Expanded, the Social Sciences Citation Index и the Arts & Humanities Citation Index. Web of Science предлагает качество и глубину контента для исследователей, авторов, издателей и учреждений. Включение Известия НАН РК в Emerging Sources Citation Index демонстрирует нашу приверженность к наиболее актуальному и влиятельному контенту по химическим наукам для нашего сообщества.

A series of pseudo-thiohydantoins and their 5-arylidene derivatives have been synthesized. Reactions of acid hydrolysis of pseudo-thiohydantoins with the formation of the corresponding 5-arylidene-3-b-aminothiazolid-2,4-one hydrochlorides have been performed. The antifungal activity of the synthesized compounds has been evaluated.

Keywords: methacryloylthiosemicarbazide of isonicotinic acid, intramolecular heterocyclization, X-ray crystallography.Previously the synthesis was reported of β-N-(methacryloylcarbamothioyl)isonicotinohydrazide (1) which, on boiling in 2-propanol for 10-16 h, underwent intramolecular cyclization to give β-N-(5-methyl-4-oxo-5,6-dihydro-4H-1,3-thiazin-2-yl)isonicotinohydrazide (2) [1]. The objective of the present work includes the study of the reaction of thiosemicarbazide 1 with a series of amines with the aim of obtaining the corresponding products of nucleophilic addition at the activated C=C bond.However mixing compound 1 with equimolar quantities of cyclic secondary amines (morpholine, piperidine) or alkaloids (anabasine, cytosine) in ethanol or 2-propanol solutions at about 30°C gave not the expected addition products 3 but the product of heterocyclization of compound 1 -the substituted 5,6-dihydro-1,3-thiazin-4-one 2 in 82% yield. Under these conditions cyclization of compound 1 occurred considerably faster (~1 h) than the same reaction in boiling 2-propanol reported previously [1]. The yield of product 2 did not depend on either the structure or the basicity of the amine and alkaloid starting materials.It is probable that the presence of base in the reaction medium facilitates the formation of the thiol form of compound 1 which is necessary for its cyclization. The 1 H NMR and IR spectra of samples of compound 2 obtained by using various amines or on boiling in 2-propanol [1] were identical.

Background. The research results of fat-soluble vitamin D3 (cholecalciferol) encapsulation with β-cyclodextrin have been presented in this work. The vitamin D3 inclusion complex with β-cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the β-cyclodextrin : vitamin D3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1H and 13C NMR spectroscopy. The existence of β-cyclodextrin inclusion complex with vitamin D3 in a 2 : 1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of β-cyclodextrin with vitamin D3 was calculated using four different methods.