Mango fruits and mango leaf extracts (Mangifera indica) are a medicinal plant used to treat diabetes and its complications. The tender leaves of the mango tree contain tannins called anthocyanidins, which help treat early diabetes. The leaves contain the compound 3-betataraxerol and ethyl acetate extract, which interacts with insulin, activating GLUT4 and stimulating glycogen synthesis. Mango leaves have powerful antioxidant properties because they contain a large amount of flavonoids, phenols, zeaxanthin and beta-carotene. Animal studies have shown that mangiferin can counteract the free radical associated with cancer, diabetes, and other diseases.