When studying the structure of intercentral relations reflected in electrical activity of different brain parts, we use calculation of complex function of coherence (Coh). High level of Coh between electrical processes indicates that they originate from the same source or that the sources of these processes are functionally related. The level of Coh between functionally separate parts will be low.The goal of our study was to examine the level of intrahemispheric Coh in patients suffering from organic pseudoneurotic disorders F06.3–F06.8 and F07.0–F07.8 according to ICD-10 and neuroses (stress-related disorders) F 4.We examined 100 healthy people, 100 patients with organic pseudoneurotic disorders and 65 patients with stress-related disorders aged 18–50. Pseudoneurotic symptomatology in patients with pseudoneurotic disorders was represented with asthenovegetative, asthenodepressive, emotionally labile and anxiety disorders occurring as a result of cerebral injuries, neuroinfections, and chronic vascular processes. The same symptomatology was observed in patients with neuroses. The study was conducted on 16-channel encephalograph “Mitsar” in spectral and coherent analysis modes.Coh was detected in left and right hemispheres.The level of intrahemispheric coherence of all rhythms (especially of beta-rhythm) was Identically increased in both hemispheres, more evidently in electrode pairs: frontopolar and temporal, temporal and occipital, central and occipital in both group of patients. There were no differences revealed in intrahemispheric coherence rates between patients with organic pseudoneurotic disorders and with neuroses.

BACKGROUND. The relevance of studying psychopathological symptoms in patients with somatoform disorders is due to the current situation around the study of the mechanisms of development and course of this pathology. AIM. To study the features of the manifestation of psychopathological symptoms in patients with somatoform disorders for subsequent consideration in conducting of therapeutic and diagnostic measures. MATERIAL AND METHODS. The study involved 125 respondents who were divided into a main group [patients diagnosed with somatoform disorder (F45)] and a control group (potentially healthy people). To study psychopathological symptoms, the SCL-90-r questionnaire was used a questionnaire on the severity of psychopathological symptoms in the adaptation of N.V. Tarabrina. The study of social factors was carried out using the developed authors questionnaire to identify social factors. The diagnosis was verified in accordance with the research criteria of the International Classification of Diseases of the 10th revision. RESULTS. The results obtained indicate statistically significant differences in the manifestations of psychopathological symptoms in patients with somatoform disorders and healthy people. In the main group above, psychopathological symptoms are expressed according to the scales Somatization U=307.500; Z=7.32; p 0.001; Interpersonal sensitivity U=809; Z=4.64; p=0.000003; Depression U=557; Z=5.98; p 0.001; Anxiety U=413; Z=6.78; p 0.001; Phobia-phobic anxiety U=573.500; Z=6.16; p 0.001 compared to control group. The presence of traumatic situations at school, income dissatisfaction, parenting style in the family, marital status, psychological violence at work, etc. affect the severity of psychopathological symptoms in patients with somatoform disorders (p 0.05). CONCLUSION. Patients with somatoform disorders have high manifestations of psychopathological symptoms that occur under the influence of social factors, compared with healthy people.

В обзоре литературы приведены данные о биологических маркерах, влияющих на эффективность и безопасность применения психотропных лекарственных средств при шизофрении. Оценка совокупности данных о наличии в генотипе пациента полиморфизмов генов изоферментов системы цитохрома Р450, транспортного белка Р-гликопротеина, молекул – мишеней психотропных лекарственных средств и функционально связанных с ними белков, а также данных о «метаболическом фенотипе» пациента может быть полезна при выборе тактики лечения. The literature review provides data on biological markers that affect the efficacy and safety of psychotropic drugs in schizophrenia. Assessment of the data on the presence of polymorphisms of genes of isoenzymes of the cytochrome P450 system, P-glycoprotein transport protein, target molecules of psychotropic drugs, and proteins functionally associated with them in the patient’s genotype, as well as the data on the patient’s “metabolic phenotype” can be useful in choosing the tactics of treatment.