The paper shows the main vectors of development of professional success of medical specialists in the context of modernization of modern medical practice. Based on the results of the analysis of modern requirements in the doctor as a subject of professional activity, psychological markers of its success are allocated. The article analyzes professionally significant personal qualities that act as internal determinants of successful professional activity of a modern doctor: moral, socio-psychological, emotional-volitional, as well as characteristics that act as markers of subjectivity formation: moral qualities, socio-psychological qualities, emotional-volitional qualities that allow to form and develop a competent style of professional behavior. The role of self - knowledge, reflection and professional self-consciousness of medical students in the effectiveness of their professional and personal growth and development of competence is shown. Based on the analysis of the results of empirical research, the article describes the content features of the views of modern medical students regarding the determinants of professional success, resources and risks of their development, shows the features of the severity of a number of psychological characteristics of modern medical students. The conceptual scheme of formation of psychological determinants of professional and personal growth of medical students is presented.