Detection and correction of structural tumor-associated epilepsy remain relevant at the present time. Seizures occur in 7590% of cases in patients with gliomas of malignancys various degrees. The aim of this work was to clarify the links of pathogenesis and clinical and neurophysiological features of structural epilepsy in intracerebral tumors. Materials and methods. We examined 23 patients with intracerebral tumors and symptomatic epilepsy. Results. Epileptiform activity was registered in 2 or more regions in more than half of the patients 12 people (52.18%), and 7 of them (58.3%) it spread to neighboring leads. No association was found between the size of the tumor and the number of attacks. Conclusions. Grade III tumors predominate among patients with tumor-related epilepsy. In this population with a high frequency after surgery, both tumor control and freedom from seizures can be achieved. It is necessary to manage this group of patients after surgery with regular neurophysiological monitoring (MRI, positron-emission tomography and video-EEG monitoring) to correct antiepileptic therapy and maintain a high level of quality of life.

Tumor-related epilepsy is of interest among the symptomatic epilepsy, that develops in 75% of patients with gliomas low-grade (astrocytomas, oligodendrogliomas — Gr II) and more than 95% of patients with glioneuronal tumors (ganglioglioma — Gr I). Currently, the nature of epileptogenic activity in brain tumors is still controversial, and the search for epileptogenic foci that are part of the tumor zone presents certain difficulties. The authors described the structural changes and metabolism in the tumor and peritumoral zone, immunological status, and molecular genetic features of the tumor, which may explain the pathogenesis of tumor-related epilepsy. In turn, the clarification of the mechanisms of epileptogenesis is a prerequisite for the development of therapeutically effective anticonvulsants, and to improve the strategies of complex treatment of tumors associated with epilepsy.