к. м. н., врач-онколог, радиотерапевт Б.П. Олимов 1 , аспирант В.О. Панов 1 , к. м. н., доцент кафедры рентгенологии и радиологии, вед. науч. сотр. С.И. Ткачев 2 , д. м. н., профессор, вед. науч. сотр. Ю.В. Буйденок 2 , д. м. н., вед. науч. сотр. Н.Л. Шимановский 3 , чл.-корр. РАН, д. м. н., профессор, заведующий кафедрой молекулярной фармакологии и радиобиологии М.А. Шориков 2 , врач-рентгенолог И.Е. Тюрин 1 , д. м. н., профессор, заведующий кафедрой рентгенологии и радиологии Б.И. Долгушин 2 , академик РАН, д. м. н., профессор, руководитель отдела лучевой диагностики и рентгенохирургических методов диагностики и лечения

Рак предстательной железы (РПЖ) -одно из наи-более часто встречающихся новообразований у муж-чин среднего и пожилого возраста. С возрастом риск развития данного заболевания возрастает на 3-4 % в год [1]. Вероятность обнаружения РПЖ у мужчины в возрасте 40-59 лет составляет 1:78 (1,28 %), в возра-

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The purpose of study is to evaluate the role of dynamic contrast intensification as a constituent of multi-parametric MR-therapy in diagnostic of clinical recurrence of prostate cancer and optimization of salutary X-ray therapy. Materials and method. The sampling consisted of 89 patients with marker (prostate specific antigen) prostate cancer recurrence after radical prostate ectomy. The preliminary examination established no distant metastases. The multi-parametric MR-imaging of pelvis minor was applied both before salutary X-ray therapy and 6 months later after with purpose of applied treatment control. In 44 patients’ analysis was applied to data of dynamic MR-imaging with contrast intensification constituent to multi-parametric MR-imaging with intravenous injection of various MR-mediums (1M Gadobutrol, ½M Gadodiamid and ½M Gadoversetamid). The results. The model of multiple linear regression was applied to demonstrate that square of substrate of clinical recurrence statistically reliably correlates with level of marker of prostate specific antigen (R = 0,74; p < 0,0008) independently of type of injected various MR-mediums. The sensitivity of multi-parametric MR-imaging in detection of clinical recurrence of prostate cancer was evaluated by comparison with levels of prostate specific antigen and amounted to 92%, specificity - to 82%, accuracy - to 88%. The application of technique of hypo-fractionating of radiation dose on area of clinical recurrence of prostate cancer detected by multi-parametric MR-imaging demonstrated more progressive decreasing of marker of prostate specific antigen as compared with standard scheme of salutary X-ray therapy (according McNemarre criterion p < 0,03). The statistically reliable dependence (Mann-Whitney criterion p < 0,018) of alteration of signal in case of dynamic MR-imaging with contrast intensification after intravenous injection of various MR-mediums from square of substrate of clinical recurrence of prostate cancer and initial concentration of injected various MR-mediums between 1M Gadobutrol and ½M Gadodiamid and ½M Gadoversetamid. Conclusion. The multi-parametric MR-imaging has high sensitivity, specificity and accuracy in detection of substrate of clinical recurrence of prostate cancer. The application of in initial concentration of 1M (Gadobutrol) reliably increase validity of detection of local clinical relapse of prostate cancer especially in case of detection of substrate of recurrence of enough little and extra-little sizes. The application of multi-parametric MR-imaging using various MR-mediums marker in initial concentration of 1M (Gadobutrol) prior to course of salutary X-ray therapy enables to plan a supposed zone of X-ray impact with the purpose of more personalized brining of of high tumorocide dose of radiation at the area of clinical recurrence of prostate cancer needed for full resorption of recurrent tumor.