The content analysis of key concepts of STEM is conducted. The essence of the new approach in education is established. The relevance of STEM education is related to the requirements of the world labor market. The content of the most demanded in the labor market of the XXI century, competencies and skills are presented in the article. The purpose, task, structure, content and expected results of the introduction and development of STEM-education in Ukraine are determined. Accordance of STEM-education with the conceptual foundations for the development of the "New Ukrainian School" is defined. The main definitions of STEM-education are offered. It was noted that a special place in the formation of its content is transdisciplinary approach, cognitive technologies in the organization of cognitive activity. Possible ways of further development of STEM-learning in Ukrainian education are considered.