No abstract

Lewis acid catalyzed mercaptolysis of steroidal SapogeninS was reinvestigated. Besides obtaining the reported 26-thioacetals 5 under milder conditions, a new type of compounds Am(a)-furostena26-thioethers 6 were also synthesized through the mercaptolysis of steroidal sapogenins, which can be used to the synthesis of the steroidal molecule with side chains.

Cyclocondensation of a-fluoroalkyl ketones or a-fluoroalkyl aldehyde (1) and diethyl 1,3-acetonedicarboxylate (2) dords 3-fluoroakyl-2,6diethoorycarbonyl-5-akyl-phenob (3) in good yields. This provides a novel method for the preparation of rneta-fluoroakyl polysubstituted phenols.