No abstract

2R,3R)-1,4-dimethoxy-1,1,4,4-tetraphenylbutane-2,3-diol has found diverse applications in asymmetric organic synthesis, and this paper briefly introduced the progress of its synthetic methods from the perspective of green chemistry. Our group developed new synthetic methods based on region-selective transformation of (2R,3R)-1,1,4,4tetraphenylbutanetetraol. In this preparation, methanol was used as a methylating reagent and common inorganic alkali liquor was used instead of DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) and LiAlH4.