Being an axial chiral compound with optical activity, 2,2'-naphthol (BINOL) has become one of the basic units for constructing various chiral fluorescent chemosensors in recent years. According to the literatures, chiral BINOL derivatives chemosensors carry out highly enantioselective, sensitive recognition of amino acid and its derivatives, chiral amino alcohols, and α-hydroxycarboxylic acids. In this progress, BINOL derivatives as enantioselective chemosensors for chiral enantiomers are summarized.

Trivalent chromium (Cr 3＋) plays an important role in the metabolismof fats, nucleic acids, carbohydrates and proteins. Moreover, Cr 3＋ is considered to be a carcinogen and is extremely harmful to humans. Therefore, Cr 3＋ fluorescent probe L was synthesized by reaction of 8-hydroxyquinolinaldehyde with thiocarbazone. The probe L showed high selectivity towards Cr 3＋ ion through the color of solution changed from colorless to yellow for naked-eye detection and significant fluorescence intensity enhanced in CH 3 CN/H 2 O (V∶V＝1∶2, Tris buffer 50 mmol/L, pH＝7.3) solution. The 1∶1 binding stoichiometry between probe and Cr 3＋ was determined from Job's plot, fluorescence titration, ESI-MS and density functional theory (DFT) calculations. The association constant (K a) and the detection limit for Cr 3＋ were found to be to be 1.00×10 5 and 2.85×10-7 mol/L, respectively. Moreover, bioimaging experiments showed that L could sense Cr 3＋ ion in living cells with a fluorescence enhancement signal. Keywords Cr 3＋ ; fluorescent probe; DFT; bioimaging 三价铬(Cr 3＋)是人体中重要的微量元素, 一般情况 下由人类和自然资源释放到环境中的过渡金属通过食 物链在人体中积累. 其中, Cr 3＋ 离子对维持有效的碳水 化合物、脂质和蛋白质的代谢起着重要的作用. 然而, Cr 3＋ 离子却被认为是一种致癌物质, 对人类的健康具有 极大的危害 [3]. 世界卫生组织(WHO)规定饮用水中 Cr 3＋ 离子的最大浓度为 50 μg/L, 正常人每天需要吸收 25～ 35 μg 的 Cr 3＋ 离子以改善葡萄糖和脂肪的代谢. 人体内