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In order to find new cyanoacrylate lead compounds, a series of novel cyanoacrylates carrying 1,3,4-oxadiazole moiety were prepared by the method of active substructure combination. The structures of the title compounds were characterized by 1 H NMR, 13 C NMR and elemental analysis. Preliminary bioassay data displayed that in postemergence treatment compound 8b had 80% herbicidal activity against Stellaria media at 1500 g/ha and compound 8j showed 70% herbicidal activity against Chenopodium serotinum L. at 1500 g/ha. Additionally, compounds 8e, 8k, 8m and 8n exhibited good anti-tumor activity against HepG2 cells with the IC 50 values of 8.2, 5.9, 8.0 and 12.6 μmol/L, respectively.

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In search of novel 1,1-dichloropropene compounds with potent bioactivities, a series of novel 1,1-dichloropropene derivatives containing N-heterocycles were synthesized by the strategy of active substructure combination. The structures of the target compounds were confirmed by 1 H NMR, 13 C NMR and elemental analysis. Preliminary bioassay indicated that most of the title compounds showed good larvicidal activity against Oriental armyworm at the concentration of 500 μg/mL. For example, the inhibition rates against Oriental armyworm of compounds 6a, 6b, 6c, 6d, 6e, 6f, 6i, 6l, 6m and 6o were all 100%. Besides, some target compounds displayed certain insecticidal activity against Aphis craccivora at the concentration of 500 μg/mL.

Fourteen novel pyrazole oxime ether derivatives containing a 2-chloro-5-methyl pyridyl ring were synthesized by the reaction of 1-phenyl-3-methyl-5-aryloxy-1H-pyrazole-4-carbaldehyde oximes with 2-chloro-5-chloromethyl pyridine. The structures of all new compounds were confirmed by 1 H NMR, 13C NMR spectra and elemental analysis. Preliminary bioassay results indicated that some compounds exhibited certain fungicidal and plant growth regulatory activities.